GNE, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

GNE, glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

• The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, N-acylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, DMRV, GLCNE, IBM2, NM, Uae1,)
• NCBI Gene ID: 10020
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y223
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase interacts with:

• ADAMTS like 4
  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
  chromosome 2 open reading frame 68
  chromosome 22 open reading frame 39
  cysteine rich tail 1
  developmental pluripotency-associated 3
  EGF like domain multiple 7
  glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  GTP binding protein 3, mitochondrial
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 11-1
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 13-2
  keratin associated protein 13-3
  keratin associated protein 17-1
  keratin associated protein 19-2
  keratin associated protein 19-7
  keratin associated protein 3-1
  keratin associated protein 3-3
  keratin associated protein 4-1
  keratin associated protein 4-11
  keratin associated protein 4-12
  keratin associated protein 4-4
  keratin associated protein 6-1
  keratin associated protein 6-2
  keratin associated protein 6-3
  keratin associated protein 9-2
  keratin associated protein 9-3
  keratin associated protein 9-8
  keratinocyte proline rich protein
  NBPF member 19
  nidogen 2
  notch 2 N-terminal like A
  pleckstrin homology domain containing A4
  potassium channel tetramerization domain containing 12
  prickle planar cell polarity protein 4
  RAB3 GTPase activating non-catalytic protein subunit 2
  RAB3 GTPase activating protein catalytic subunit 1
  replication timing regulatory factor 1
  RNA binding motif protein 12
  scavenger receptor cysteine rich family member with 4 domains
  sprouty RTK signaling antagonist 1
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 3
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  translocase of inner mitochondrial membrane 50
  tripartite motif containing 42
  tRNA splicing endonuclease subunit 34
  von Willebrand factor C domain containing 2
  WD repeat domain 83
  WW domain containing oxidoreductase
  zinc finger protein 764

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.