TIRAP, TIR domain containing adaptor protein

TIRAP, TIR domain containing adaptor protein

• The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (BACTS1, Mal, MyD88-2, wyatt, toll/interleukin-1 receptor domain-containing adapter protein, MyD88 adapter-like protein, Toll-like receptor adaptor protein, adapter protein wyatt, adaptor protein Wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein,)
• NCBI Gene ID: 114609
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R3M4
  UNIPROT ID#>>P58753
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TIR domain containing adaptor protein interacts with:

• BTB domain containing 9
  phosphoinositide-3-kinase adaptor protein 1
  TIR domain containing adaptor protein
  toll like receptor adaptor molecule 1
  toll like receptor adaptor molecule 2
  ubiquitin protein ligase E3 component n-recognin 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.