ERAP1, endoplasmic reticulum aminopeptidase 1

ERAP1, endoplasmic reticulum aminopeptidase 1

• The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

• Gene Synonyms (endoplasmic reticulum aminopeptidase 1, CTD-2260A17.2, adipocyte-derived leucine aminopeptidase, aminopeptidase PILS, aminopeptidase regulator of TNFR1 shedding, endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform, endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform, endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform, endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform, endoplasmic reticulum aminopeptidase associated with antigen processing, puromycin-insensitive leucyl-specific aminopeptidase, type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, A-LAP, ALAP, APPILS, ARTS-1, ARTS1, ERAAP, ERAAP1, PILS-AP, PILSAP,)
• NCBI Gene ID: 51752
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NZ08
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

endoplasmic reticulum aminopeptidase 1 interacts with:

• ER degradation enhancing alpha-mannosidase like protein 3
  killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
  mitochondrial E3 ubiquitin protein ligase 1
  P2Y receptor family member 8
  pleckstrin homology domain containing A4
  reactive oxygen species modulator 1
  secretoglobin family 1D member 4
  sialic acid acetylesterase
  solute carrier family 16 member 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.