TFAP2A, transcription factor AP-2 alpha

TFAP2A, transcription factor AP-2 alpha

• The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

• Gene Synonyms (transcription factor AP-2-alpha, AP-2 transcription factor, activating enhancer-binding protein 2-alpha, activator protein 2, transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha), AP-2, AP-2alpha, AP2TF, BOFS, TFAP2,)
• NCBI Gene ID: 7020
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P05549
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor AP-2 alpha interacts with:

• acyl-CoA thioesterase 1
  adaptor related protein complex 1 subunit mu 2
  adaptor related protein complex 4 subunit epsilon 1
  anti-silencing function 1A histone chaperone
  BAG cochaperone 3
  Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
  Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
  cell division cycle 6
  DEK proto-oncogene
  embryonic ectoderm development
  epsin 1
  epsin 2
  eukaryotic elongation factor, selenocysteine-tRNA specific
  FCH and mu domain containing endocytic adaptor 1
  FCH domain only 2
  forkhead box B1
  glutathione S-transferase omega 2
  glycogen synthase kinase 3 beta
  H4 clustered histone 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  histone cell cycle regulator
  inhibitor of CDK, cyclin A1 interacting protein 1
  low density lipoprotein receptor adaptor protein 1
  makorin ring finger protein 3
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  N(alpha)-acetyltransferase 50, NatE catalytic subunit
  potassium channel tetramerization domain containing 1
  potassium channel tetramerization domain containing 15
  SH3 domain binding protein 4
  small ubiquitin like modifier 4
  steroid receptor RNA activator 1
  transcription factor AP-2 beta
  transcription factor AP-2 delta
  transcription factor AP-2 gamma
  tumor protein p53
  ubinuclein 1
  ubiquitin conjugating enzyme E2 I
  vascular endothelial growth factor A
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  YY1 transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.