TGFBR1, transforming growth factor beta receptor 1

TGFBR1, transforming growth factor beta receptor 1

• The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

• Gene Synonyms (TGF-beta receptor type-1, activin A receptor type II-like kinase, 53kDa, activin A receptor type II-like protein kinase of 53kD, activin receptor-like kinase 5, mutant transforming growth factor beta receptor I, serine/threonine-protein kinase receptor R4, transforming growth factor beta receptor I, transforming growth factor-beta receptor type I, AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I,)
• NCBI Gene ID: 7046
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DXN7
  UNIPROT ID#>>Q5T7S2
  UNIPROT ID#>>P36897
  UNIPROT ID#>>B4DY26
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transforming growth factor beta receptor 1 interacts with:

• adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  ADP ribosylation factor like GTPase 8B
  ADP-ribosylation factor-like 4D
  alpha tocopherol transfer protein like
  anaphase promoting complex subunit 5
  anaphase-promoting complex subunit 5
  ASH2 like, histone lysine methyltransferase complex subunit
  aurora kinase B
  aurora kinase B
  autophagy related 16-like 1 (S. cerevisiae)
  BCR activator of RhoGEF and GTPase
  BMP and activin membrane bound inhibitor
  bone morphogenetic protein receptor, type II (serine/threonine kinase)
  BTB (POZ) domain containing 2
  BTB domain containing 2
  casein kinase 1, alpha 1
  casein kinase 1, delta
  casein kinase 2, alpha prime polypeptide
  CDC42 effector protein (Rho GTPase binding) 4
  CDC42 effector protein 4
  cell division cycle 20
  chimerin 1
  chimerin 2
  conserved helix-loop-helix ubiquitous kinase
  cullin 5
  cullin 5
  cyclin dependent kinase like 1
  cyclin-dependent kinase 14
  cyclin-dependent kinase 17
  cyclin-dependent kinase 4
  cyclin-dependent kinase 6
  cyclin-dependent kinase-like 1 (CDC2-related kinase)
  DDB1 and CUL4 associated factor 12
  DDB1 and CUL4 associated factor 6
  death associated protein kinase 2
  death-associated protein kinase 2
  dual specificity phosphatase 10
  dual specificity phosphatase 13
  dual specificity phosphatase 6
  ectodermal-neural cortex 1
  ectodermal-neural cortex 1
  ephrin A1
  eukaryotic translation initiation factor 2 alpha kinase 1
  eukaryotic translation initiation factor 2 alpha kinase 4
  eukaryotic translation initiation factor 2 alpha kinase 4
  FA complementation group L
  Fanconi anemia, complementation group L
  F-box and leucine rich repeat protein 12
  F-box and leucine-rich repeat protein 12
  F-box and WD-40 domain protein 5
  F-box protein 24
  F-box protein 3
  F-box protein 34
  F-box protein 34
  FK506 binding protein 1a
  FK506 binding protein 1b
  G protein subunit alpha 13
  GIT ArfGAP 2
  golgi transport 1B
  guanine nucleotide binding protein (G protein), beta 2
  guanine nucleotide binding protein (G protein), beta 3
  guanine nucleotide binding protein, alpha 13
  hepatitis A virus cellular receptor 1
  IL2 inducible T cell kinase
  inhibitor of kappaB kinase beta
  integrin-linked kinase-associated serine/threonine phosphatase 2C
  interferon regulatory factor 7
  itchy E3 ubiquitin protein ligase
  katanin p80 (WD40-containing) subunit B 1
  katanin regulatory subunit B1
  kelch like family member 1
  kelch like family member 35
  kelch-like 1
  MAP kinase-interacting serine/threonine kinase 2
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase kinase 20
  myelin transcription factor 1 like
  myosin IIIA
  myosin IIIA
  N(alpha)-acetyltransferase 20, NatB catalytic subunit
  N-acetyltransferase 8 (putative)
  NADPH oxidase organizer 1
  neuroligin 3
  neuropilin 1
  NFKB inhibitor interacting Ras like 1
  NFKB inhibitor interacting Ras-like protein 1
  NIMA (never in mitosis gene a)-related expressed kinase 6
  NIMA (never in mitosis gene a)-related expressed kinase 8
  NIMA related kinase 6
  NIMA related kinase 8
  NUAK family kinase 2
  NUAK family, SNF1-like kinase, 2
  nucleoporin 37
  nucleoporin 37
  occludin
  occludin
  odd-skipped related transcription factor 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxidative stress responsive kinase 1
  par-6 family cell polarity regulator alpha
  par-6 family cell polarity regulator alpha
  paternally expressed 10
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
  pleckstrin
  pleckstrin homology domain containing B1
  pleckstrin homology domain containing J1
  pleckstrin homology domain containing, family B (evectins) member 1
  polo like kinase 4
  potassium two pore domain channel subfamily K member 18
  pre-mRNA processing factor 4
  pre-mRNA processing factor 4
  prolactin regulatory element binding
  prolactin regulatory element binding
  proteasome 26S subunit, non-ATPase 14
  protein O-mannose kinase
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 16B
  protein phosphatase 3, catalytic subunit, gamma isoform
  protein phosphatase 6, catalytic subunit
  RAB13, member RAS oncogene family
  RAB25, member RAS oncogene family
  RAB33B, member RAS oncogene family
  RAB33B, member RAS oncogene family
  RAB34, member RAS oncogene family
  RAB34, member RAS oncogene family
  RAB38, member RAS oncogene family
  RAB38, member RAS oncogene family
  RAB3B, member RAS oncogene family
  RAB6B, member RAS oncogene family
  RAB6B, member RAS oncogene family
  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
  Rac/Cdc42 guanine nucleotide exchange factor 6
  RAN binding protein 9
  Ras association domain family member 1
  Ras homolog enriched in brain like 1
  ras homolog family member A
  ras homolog family member D
  ras homolog family member D
  ras homolog family member H
  ras homolog family member J
  ras homolog family member J
  RAS like family 12
  RAS related protein 2a
  RASD family member 2
  RASD family, member 2
  regulator of G protein signaling 19
  regulator of G-protein signaling 19
  retinal pigment epithelium derived rhodopsin homolog
  retinal pigment epithelium-derived rhodopsin homolog
  RHEB like 1
  Rho GTPase activating protein 15
  Rho GTPase activating protein 15
  Rho GTPase activating protein 31
  Rho GTPase activating protein 31
  rhophilin Rho GTPase binding protein 2
  rhophilin, Rho GTPase binding protein 2
  Rho-related BTB domain containing 1
  rhotekin
  ribosomal protein S27A
  ring finger protein 130
  ring finger protein 130
  ring finger protein 138
  ring finger protein 146
  RNA polymerase II associated protein 3
  scribble planar cell polarity protein
  sequestosome 1
  serine/threonine kinase 35
  serine/threonine kinase 35
  serine/threonine kinase receptor associated protein
  serine/threonine/tyrosine interacting like 1
  SH3 domain containing kinase binding protein 1
  signal transducer and activator of transcription 1
  SMAD family member 7
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  sorting nexin 6
  spermidine/spermine N1-acetyltransferase family member 2
  src family associated phosphoprotein 2
  src kinase associated phosphoprotein 2
  sterile alpha motif domain containing 8
  sterile alpha motif domain containing 8
  STIP1 homology and U-box containing protein 1
  STIP1 homology and U-Box containing protein 1
  suppressor of cytokine signaling 6
  syntaxin 8
  syntaxin 8
  syntrophin gamma 1
  syntrophin, gamma 1
  testis specific serine kinase 1B
  testis specific serine kinase 4
  testis-specific serine kinase 3
  testis-specific serine kinase 5
  tetratricopeptide repeat domain 1
  tetratricopeptide repeat domain 1
  tetratricopeptide repeat domain 27
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TNF receptor associated factor 4
  TNF receptor associated factor 6
  TNF receptor associated protein 1
  toll interacting protein
  transforming growth factor beta receptor 1
  transforming growth factor beta receptor 2
  transforming growth factor beta receptor associated protein 1
  transforming growth factor, beta receptor I
  tripartite motif containing 25
  tropomyosin 1
  troponin T1, slow skeletal type
  TSC22 domain family member 1
  tumor protein p63
  U2AF homology motif (UHM) kinase 1
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin B
  ubiquitin B
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 Z
  ubiquitin D
  ubiquitin D
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 4
  ubiquitin specific peptidase 45
  ubiquitin specific petidase 45
  ubiquitin-conjugating enzyme E2E 3
  UBX domain protein 1
  ventricular zone expressed PH domain containing 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WD repeat and SOCS box-containing 1
  WD repeat domain 13
  WD repeat domain 13
  WD repeat domain 33
  WD repeat domain 61
  WD repeat domain 61
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger FYVE-type containing 9

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.