CFLAR, CASP8 and FADD like apoptosis regulator

CFLAR, CASP8 and FADD like apoptosis regulator

• The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

• Gene Synonyms (CASP8 and FADD-like apoptosis regulator, FADD-like antiapoptotic molecule 1, MACH-related inducer of toxicity, caspase homolog, caspase-eight-related protein, caspase-like apoptosis regulatory protein, caspase-related inducer of apoptosis, cellular FLICE-like inhibitory protein, inhibitor of FLICE, testis secretory sperm-binding protein Li 233m, usurpin beta, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP,)
• NCBI Gene ID: 8837
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E361
  UNIPROT ID#>>Q59F61
  UNIPROT ID#>>A0A024R3Y3
  UNIPROT ID#>>E9PAP3
  UNIPROT ID#>>O15519
  UNIPROT ID#>>A0A024R3Z7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CASP8 and FADD like apoptosis regulator interacts with:

• autophagy related 3
  CASP8 and FADD like apoptosis regulator
  death effector domain containing
  death effector domain containing 2
  docking protein 2
  glucocorticoid modulatory element binding protein 1
  itchy E3 ubiquitin protein ligase
  mindbomb E3 ubiquitin protein ligase 1
  mitogen-activated protein kinase kinase kinase 14
  nucleolar protein 3
  nucleotide binding oligomerization domain containing 1
  perilipin 5
  protein arginine methyltransferase 5
  ring finger protein 31
  spermatogenesis associated serine rich 1
  splicing factor 3b subunit 3
  STIP1 homology and U-box containing protein 1
  toll like receptor adaptor molecule 1
  ubiquitin specific peptidase 40
  ubiquitin specific peptidase 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.