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NOD1, nucleotide binding oligomerization domain containing 1

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NOD1, nucleotide binding oligomerization domain containing 1

  • This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017]

  • Gene Synonyms (CARD4, CLR7.1, NLRC1, nucleotide-binding oligomerization domain-containing protein 1, NLR family, CARD domain containing 1, caspase recruitment domain family, member 4, caspase recruitment domain-containing protein 4, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1,)
  • NCBI Gene ID: 10392
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>Q9Y239
    UNIPROT ID#>>G3XAL1
    UNIPROT ID#>>A0A024RA73
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nucleotide binding oligomerization domain containing 1 interacts with:

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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