PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F

PPM1F, protein phosphatase, Mg2+/Mn2+ dependent 1F

• The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein phosphatase 1F, Ca(2+)/calmodulin-dependent protein kinase phosphatase, CaM-kinase phosphatase, PP2C phosphatase, partner of PIX 2, protein fem-2 homolog, protein phosphatase 1F (PP2C domain containing), CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2,)
• NCBI Gene ID: 9647
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49593
  UNIPROT ID#>>B5MCT7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase, Mg2+/Mn2+ dependent 1F interacts with:

• centrosomal protein 164
  FAM161 centrosomal protein A
  F-box protein 6
  fem-1 homolog A
  fem-1 homolog B
  kelch like family member 8
  lemur tyrosine kinase 2
  limb development membrane protein 1 like
  mucin 20, cell surface associated
  ninein
  N-myc downstream regulated 1
  pleckstrin homology domain containing A4
  protein phosphatase, Mg2+/Mn2+ dependent 1F
  translocase of outer mitochondrial membrane 22
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.