TOPORS, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

TOPORS, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

• This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

• Gene Synonyms (E3 ubiquitin-protein ligase Topors, RING-type E3 ubiquitin transferase Topors, SUMO1-protein E3 ligase Topors, TOP1 binding arginine/serine rich protein, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase, topoisomerase I-binding RING finger protein, tumor suppressor p53-binding protein 3, LUN, P53BP3, RP31, TP53BPL,)
• NCBI Gene ID: 10210
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NS56
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase interacts with:

• hyaluronan binding protein 4
  metadherin
  NFKB activating protein
  nucleolar protein interacting with the FHA domain of MKI67
  polyglutamine binding protein 1
  SERPINE1 mRNA binding protein 1
  SIN3 transcription regulator family member A
  Smad nuclear interacting protein 1
  spindlin 1
  spindlin family member 2B
  splicing factor 3b subunit 1
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  transformation related protein 53
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 J1
  ubiquitin conjugating enzyme E2 W
  UBX domain protein 7
  UPF3A regulator of nonsense mediated mRNA decay
  zinc finger CCCH-type containing 18
  zinc finger protein 324B
  zinc finger protein 786
  zinc finger protein 816

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.