NKAP, NFKB activating protein

NKAP, NFKB activating protein

• This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]

• Gene Synonyms (NF-kappa-B-activating protein, NF-kappaB activating protein, MRXSHD,)
• NCBI Gene ID: 79576
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N5F7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NFKB activating protein interacts with:

• centrosomal protein 70
  chromodomain helicase DNA binding protein 9
  chromosome 1 open reading frame 226
  family with sequence similarity 124 member A
  FRA10A associated CGG repeat 1
  HECT domain E3 ubiquitin protein ligase 3
  NFKB activating protein
  NFKB activating protein like
  ring finger and CCCH-type domains 1
  round spermatid basic protein 1 like
  Smad nuclear interacting protein 1
  SREK1 interacting protein 1
  tetratricopeptide repeat domain 14
  zinc finger CCCH-type containing 18

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.