SIGMAR1, sigma non-opioid intracellular receptor 1

SIGMAR1, sigma non-opioid intracellular receptor 1

• This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

• Gene Synonyms (ALS16, DSMA2, OPRS1, SIG-1R, SR-BP, SR-BP1, SRBP, hSigmaR1, sigma1R, sigma non-opioid intracellular receptor 1, SR31747 binding protein 1, aging-associated gene 8 protein, sigma 1-type opioid receptor,)
• NCBI Gene ID: 10280
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A2A3U5
  UNIPROT ID#>>B4DR71
  UNIPROT ID#>>Q99720
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sigma non-opioid intracellular receptor 1 interacts with:

• adhesion G protein-coupled receptor G5
  developmental pluripotency-associated 3
  integrin alpha FG-GAP repeat containing 1
  limb development membrane protein 1 like
  nuclear RNA export factor 1
  PDZ domain containing 11
  pleckstrin homology domain containing A4
  tectonic family member 3
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.