UNC13B, unc-13 homolog B

UNC13B, unc-13 homolog B

• This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MUNC13, UNC13, Unc13h2, munc13-2, protein unc-13 homolog B, homolog of rat Munc13 (diacylglycerol-binding), unc-13-like,)
• NCBI Gene ID: 10497
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14795
  UNIPROT ID#>>Q4LE73
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

unc-13 homolog B interacts with:

• coiled-coil domain containing 40
  DIRAS family GTPase 2
  phosducin like 2
  regulating synaptic membrane exocytosis 1
  syntaxin 1B
  target of EGR1, exonuclease
  UBX domain protein 10
  vir like m6A methyltransferase associated
  WD repeat domain 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.