MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5

MAP4K5, mitogen-activated protein kinase kinase kinase kinase 5

• This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (mitogen-activated protein kinase kinase kinase kinase 5, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, MEKKK 5, germinal center kinase-related, kinase homologous to SPS1/STE20, GCKR, KHS, KHS1, MAPKKKK5,)
• NCBI Gene ID: 11183
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y4K4
  UNIPROT ID#>>B3KWC4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase kinase 5 interacts with:

• CMT1A duplicated region transcript 15
  pleckstrin homology domain containing A4
  SMAD specific E3 ubiquitin protein ligase 1
  zinc finger protein 440

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.