Eif4e, eukaryotic translation initiation factor 4E

Eif4e, eukaryotic translation initiation factor 4E

• This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• (No alternate names found)
• NCBI Gene ID: 13684
• Species: Mus musculus (Mouse)
• UNIPROT ID#>>A0A0G2JFB4
  UNIPROT ID#>>P63073
  UNIPROT ID#>>Q8C470
  UNIPROT ID#>>Q3TK95
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 4E interacts with:

• AHA1, activator of heat shock protein ATPase 1
  argonaute RISC catalytic subunit 2
  ataxin 2
  ataxin 2-like
  cytoplasmic FMR1 interacting protein 1
  cytotoxic granule-associated RNA binding protein 1
  DEAD box helicase 1
  DIS3 like 3'-5' exoribonuclease 2
  eukaryotic translation initiation factor 3, subunit B
  eukaryotic translation initiation factor 4 gamma, 3
  eukaryotic translation initiation factor 4, gamma 1
  eukaryotic translation initiation factor 4, gamma 2
  eukaryotic translation initiation factor 4E
  eukaryotic translation initiation factor 4E binding protein 1
  eukaryotic translation initiation factor 4E binding protein 2
  eukaryotic translation initiation factor 4E nuclear import factor 1
  FMRP translational regulator 1
  G1 to S phase transition 1
  heterogeneous nuclear ribonucleoprotein U
  IQ motif containing GTPase activating protein 1
  La ribonucleoprotein domain family, member 1
  leucine-rich PPR-motif containing
  LSM14A mRNA processing body assembly factor
  MAP kinase-interacting serine/threonine kinase 1
  MAPK regulated corepressor interacting protein 1
  myelocytomatosis oncogene
  N-acetylneuraminic acid synthase (sialic acid synthase)
  nuclear cap binding protein subunit 1
  nucleolin
  OTU deubiquitinase 4
  peptidase D
  poly(A) binding protein, cytoplasmic 1
  poly(rC) binding protein 1
  polymerase (DNA-directed), delta interacting protein 3
  proteasome (prosome, macropain) 26S subunit, ATPase 2
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  protein kinase C, beta
  Rac family small GTPase 1
  regulatory associated protein of MTOR, complex 1
  Rho-associated coiled-coil containing protein kinase 2
  ribosomal protein L13
  ribosomal protein L28
  ribosomal protein L6
  ribosomal protein S4, X-linked
  ribosomal protein S6
  RNA (guanine-7-) methyltransferase
  RNA guanine-7 methyltransferase activating subunit
  staufen double-stranded RNA binding protein 1
  tubulin, beta 5 class I
  UPF1 regulator of nonsense transcripts homolog (yeast)
  Y box protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.