UBR4, ubiquitin protein ligase E3 component n-recognin 4

UBR4, ubiquitin protein ligase E3 component n-recognin 4

• The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

• Gene Synonyms (RBAF600, ZUBR1, p600, E3 ubiquitin-protein ligase UBR4, N-recognin-4, RING-type E3 ubiquitin transferase UBR4, retinoblastoma-associated factor 600-like protein, retinoblastoma-associated factor of 600 kDa, zinc finger UBR1-type protein 1,)
• NCBI Gene ID: 23352
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5T4S7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin protein ligase E3 component n-recognin 4 interacts with:

• AAR2 splicing factor
  acyl-CoA synthetase medium chain family member 5
  argonaute RISC catalytic component 2
  aurora kinase A interacting protein 1
  chitinase acidic
  chromosome 1 open reading frame 87
  copine 5
  cripto, FRL-1, cryptic family 1
  crystallin lambda 1
  cystatin 9
  dual specificity phosphatase 19
  dynein 2 intermediate chain 2
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  EMI domain containing 1
  erythroblast membrane associated protein (Scianna blood group)
  forkhead box K1
  fuzzy planar cell polarity protein
  glutamate rich WD repeat containing 1
  golgi reassembly stacking protein 1
  La ribonucleoprotein 7, transcriptional regulator
  leucyl-tRNA synthetase 1
  limb development membrane protein 1 like
  methyltransferase like 2A
  mitoguardin 2
  MOB family member 4, phocein
  patatin like phospholipase domain containing 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  potassium channel modulatory factor 1
  pre-mRNA processing factor 40 homolog A
  protein arginine methyltransferase 6
  protein O-glucosyltransferase 1
  required for meiotic nuclear division 5 homolog A
  ring finger protein 123
  ring finger protein 181
  SAS-6 centriolar assembly protein
  sirtuin 7
  SLX1 homolog A, structure-specific endonuclease subunit
  solute carrier family 15 member 3
  spermatogenesis associated 1
  strawberry notch homolog 1
  testin LIM domain protein
  transcription factor Dp family member 3
  tubulin polyglutamylase complex subunit 2
  UBX domain protein 1
  UBX domain protein 7
  unc-93 homolog B1, TLR signaling regulator
  USO1 vesicle docking factor
  vir like m6A methyltransferase associated
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.