SIRT7, sirtuin 7

SIRT7, sirtuin 7

• This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

• Gene Synonyms (NAD-dependent protein deacetylase sirtuin-7, NAD-dependent deacetylase sirtuin-7, NAD-dependent protein deacylase sirtuin-7, SIR2-like protein 7, regulatory protein SIR2 homolog 7, silent mating type information regulation 2, S.cerevisiae, homolog 7, sir2-related protein type 7, sirtuin type 7, SIR2L7,)
• NCBI Gene ID: 51547
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NRC8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sirtuin 7 interacts with:

• 5'-3' exoribonuclease 1
  AHNAK nucleoprotein
  anaphase promoting complex subunit 1
  ankyrin repeat and KH domain containing 1
  ankyrin repeat domain 52
  ATPase family AAA domain containing 2B
  ATPase family AAA domain containing 3A
  baculoviral IAP repeat containing 6
  BEN domain containing 3
  biogenesis of ribosomes BRX1
  cell cycle and apoptosis regulator 2
  cell division cycle and apoptosis regulator 1
  chromodomain helicase DNA binding protein 7
  chromodomain helicase DNA binding protein 8
  cingulin
  cleavage and polyadenylation specific factor 3
  coiled-coil domain containing 86
  DDB1 and CUL4 associated factor 11
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 31
  DEAD-box helicase 51
  DEAD-box helicase 54
  DEAD-box helicase 56
  DEAH-box helicase 36
  DEAH-box helicase 37
  dedicator of cytokinesis 7
  DExH-box helicase 57
  DNA polymerase delta interacting protein 3
  epiplakin 1
  ESF1 nucleolar pre-rRNA processing protein homolog
  exportin 5
  FA complementation group I
  FRY like transcription coactivator
  FtsJ RNA 2'-O-methyltransferase 3
  glyoxylate reductase 1 homolog
  HEAT repeat containing 1
  helicase with zinc finger 2
  heterogeneous nuclear ribonucleoprotein A3
  importin 4
  isoleucyl-tRNA synthetase 2, mitochondrial
  kelch repeat and BTB domain containing 7
  KRI1 homolog
  La ribonucleoprotein 4
  La ribonucleoprotein 7, transcriptional regulator
  lamin B2
  LAS1 like ribosome biogenesis factor
  leucine rich repeat containing 47
  MAK16 homolog
  myosin heavy chain 14
  N-acetyltransferase 10
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  NFKB repressing factor
  NOC3 like DNA replication regulator
  NOP2/Sun RNA methyltransferase 2
  NOP58 ribonucleoprotein
  notchless homolog 1
  nuclear FMR1 interacting protein 2
  nuclear receptor binding SET domain protein 1
  nucleolar complex associated 4 homolog
  nucleolar protein 10
  nucleolar protein 6
  nucleolar protein 9
  nucleolar protein interacting with the FHA domain of MKI67
  nucleoporin 107
  nucleoporin 133
  oxysterol binding protein like 8
  pentatricopeptide repeat domain 3
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  PHD and ring finger domains 1
  pleckstrin homology domain interacting protein
  polybromo 1
  polyribonucleotide nucleotidyltransferase 1
  pre-mRNA processing factor 40 homolog A
  proline rich coiled-coil 2B
  protein phosphatase 6 regulatory subunit 3
  regulator of chromosome condensation 2
  remodeling and spacing factor 1
  replication timing regulatory factor 1
  REX4 homolog, 3'-5' exonuclease
  ribosome production factor 2 homolog
  RNA binding motif protein 15
  RNA binding motif protein 25
  RNA binding motif protein 28
  RNA polymerase I subunit E
  SAFB like transcription modulator
  signal recognition particle 72
  SMU1 DNA replication regulator and spliceosomal factor
  spermatid perinuclear RNA binding protein
  suppressor of glucose, autophagy associated 1
  tankyrase 1 binding protein 1
  terminal uridylyl transferase 7
  testis expressed 10
  THO complex 2
  transcription activation suppressor family member 2
  TSR1 ribosome maturation factor
  tubulin alpha 1c
  ubiquitin conjugating enzyme E2 O
  ubiquitin conjugating enzyme E2 R2
  ubiquitin specific peptidase 47
  UDP-glucose glycoprotein glucosyltransferase 1
  UTP15 small subunit processome component
  UTP4 small subunit processome component
  UTP6 small subunit processome component
  WD repeat domain 12
  WD repeat domain 18
  WD repeat domain 36
  WD repeat domain 75
  WD repeat domain 77
  XPA binding protein 2
  YLP motif containing 1
  YTH domain containing 2
  zinc finger CCCH-type containing 14
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCHC-type containing 3
  zinc finger CCHC-type containing 8
  zinc finger protein 512
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.