- Gene Overview
- Interaction Network
- Sequence Verification
ABHD12, abhydrolase domain containing 12, lysophospholipase
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This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
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Gene Synonyms (lysophosphatidylserine lipase ABHD12, 2-arachidonoylglycerol hydrolase, 2-arachidonoylglycerol hydrolase ABHD12, abhydrolase domain containing 12, abhydrolase domain-containing protein 12, monoacylglycerol lipase ABHD12, oxidized phosphatidylserine lipase ABHD12, ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2, hABHD12,)
- NCBI Gene ID:
26090
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>Q8N2K0
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
abhydrolase domain containing 12, lysophospholipase interacts with:
Paste a protein or nucleic acid sequence in the box below to confirm that it matches
this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see
how a sequence matches to an experimentally-validated ORF clone.
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