HTR1B, 5-hydroxytryptamine receptor 1B

HTR1B, 5-hydroxytryptamine receptor 1B

• The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

• Gene Synonyms (5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, serotonin 1D beta receptor, serotonin receptor 1B, 5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12,)
• NCBI Gene ID: 3351
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P28222
  UNIPROT ID#>>A8K215
  UNIPROT ID#>>X5D7I5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

5-hydroxytryptamine receptor 1B interacts with:

• 5-hydroxytryptamine receptor 1B
  5-hydroxytryptamine receptor 1D
  CD209 molecule
  glutathione S-transferase kappa 1
  MyoD family inhibitor
  NME/NM23 nucleoside diphosphate kinase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.