IFNAR1, interferon alpha and beta receptor subunit 1

IFNAR1, interferon alpha and beta receptor subunit 1

• The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]

• Gene Synonyms (interferon alpha/beta receptor 1, CRF2-1, IFN-R-1, IFN-alpha/beta receptor 1, alpha-type antiviral protein, beta-type antiviral protein, cytokine receptor class-II member 1, cytokine receptor family 2 member 1, interferon (alpha, beta and omega) receptor 1, interferon receptor 1, interferon-alpha/beta receptor alpha chain, interferon-beta receptor 1, type I interferon receptor 1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC,)
• NCBI Gene ID: 3454
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17181
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interferon alpha and beta receptor subunit 1 interacts with:

• abraxas 2, BRISC complex subunit
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRCA1/BRCA2-containing complex subunit 3
  F-box and WD repeat domain containing 11
  interferon alpha and beta receptor subunit 2
  interferon beta 1
  interferon omega 1
  LCK proto-oncogene, Src family tyrosine kinase
  lysosomal protein transmembrane 4 beta
  mitogen-activated protein kinase 1
  phosphoinositide-3-kinase regulatory subunit 1
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase D2
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type C
  pyruvate kinase M1/2
  receptor for activated C kinase 1
  serine hydroxymethyltransferase 1
  serine hydroxymethyltransferase 2
  signal transducer and activator of transcription 2
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 6
  suppressor of cytokine signaling 1
  TNF receptor superfamily member 10a
  tripartite motif containing 25
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine kinase 2
  ubiquitin like modifier activating enzyme 1
  ubiquitin specific peptidase 7
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.