ZAP70, zeta chain of T cell receptor associated protein kinase 70

ZAP70, zeta chain of T cell receptor associated protein kinase 70

• This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, syk-related tyrosine kinase, zeta chain of T cell receptor associated protein kinase 70kDa, zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70,)
• NCBI Gene ID: 7535
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43403
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

zeta chain of T cell receptor associated protein kinase 70 interacts with:

• anaphase promoting complex subunit 11
  ankyrin repeat and SOCS box containing 3
  caspase recruitment domain family member 11
  Cbl proto-oncogene C
  CD3 antigen, epsilon polypeptide
  DEF6 guanine nucleotide exchange factor
  drebrin like
  Fc receptor like 3
  GRB2 associated binding protein 2
  leucine rich repeat kinase 2
  linker for activation of T cells
  lymphocyte transmembrane adaptor 1
  NFAT activating protein with ITAM motif 1
  nuclear receptor subfamily 0 group B member 2
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  platelet endothelial aggregation receptor 1
  protein tyrosine phosphatase non-receptor type 22
  ring finger protein 41
  SH2B adaptor protein 3
  SHC adaptor protein 3
  signaling threshold regulating transmembrane adaptor 1
  SLAM family member 6
  Src like adaptor 2
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin beta class I
  ubiquitin specific peptidase 12
  ubiquitin specific peptidase 2
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.