TYK2, tyrosine kinase 2

TYK2, tyrosine kinase 2

• This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Jul 2020]

• Gene Synonyms (non-receptor tyrosine-protein kinase TYK2, IMD35, JTK1,)
• NCBI Gene ID: 7297
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P29597
  UNIPROT ID#>>A0A024R7E4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosine kinase 2 interacts with:

• Aly/REF export factor
  amine oxidase copper containing 3
  aminoadipate aminotransferase
  BAG cochaperone 2
  bromodomain containing 7
  centrosomal protein 170B
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromosome 16 open reading frame 71
  COP9 signalosome subunit 5
  cysteine rich tail 1
  DLG associated protein 4
  elongator acetyltransferase complex subunit 2
  G protein-coupled receptor 156
  geminin DNA replication inhibitor
  golgin A6 family like 9
  hepatitis A virus cellular receptor 2
  insulin receptor substrate 2
  intraflagellar transport 43
  janus kinase and microtubule interacting protein 1
  keratin 40
  keratin associated protein 6-3
  KH RNA binding domain containing, signal transduction associated 2
  KH RNA binding domain containing, signal transduction associated 3
  LDL receptor related protein 8
  leucine rich repeat containing 46
  ligand of numb-protein X 1
  lysophosphatidic acid receptor 6
  MIER family member 2
  myotubularin related protein 4
  neuroligin 3
  nuclear RNA export factor 1
  PIH1 domain containing 1
  PR/SET domain 5
  proline and serine rich 2
  protein arginine methyltransferase 5
  protein phosphatase 2, regulatory subunit A, alpha
  receptor for activated C kinase 1
  receptor interacting serine/threonine kinase 4
  ring finger protein 13
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  signal transducing adaptor molecule 2
  SIVA1 apoptosis inducing factor
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 2
  thioredoxin reductase 2
  TNF receptor associated factor 4
  TNF receptor associated protein 1
  TNF receptor superfamily member 13B
  TNF receptor superfamily member 19
  transformation related protein 53 binding protein 1
  transmembrane and coiled-coil domains 3
  tripartite motif containing 28
  tyrosine kinase 2
  ubiquitin conjugating enzyme E2 L6
  vav guanine nucleotide exchange factor 1
  WD repeat domain 20
  X-ray repair cross complementing 5
  zinc finger protein 333

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.