CXCR1, C-X-C motif chemokine receptor 1

CXCR1, C-X-C motif chemokine receptor 1

• The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C-X-C chemokine receptor type 1, CXC-R1, CXCR-1, IL-8 receptor type 1, IL-8R A, chemokine (C-X-C motif) receptor 1, high affinity interleukin-8 receptor A, interleukin 8 receptor, alpha, interleukin-8 receptor type 1, interleukin-8 receptor type A, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA,)
• NCBI Gene ID: 3577
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P25024
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-X-C motif chemokine receptor 1 interacts with:

• claudin domain containing 1
  C-X-C motif chemokine ligand 5
  C-X-C motif chemokine ligand 6
  C-X-C motif chemokine receptor 1
  C-X-C motif chemokine receptor 2
  fetal and adult testis expressed 1
  G protein subunit alpha 14
  programmed cell death 6 interacting protein
  pro-platelet basic protein
  trafficking regulator of GLUT4 (SLC2A4) 1
  tubulin alpha 1a
  ubiquitin conjugating enzyme E2 C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.