MDK, midkine

MDK, midkine

• This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

• Gene Synonyms (ARAP, MK, NEGF2, midkine, amphiregulin-associated protein, midgestation and kidney protein, neurite growth-promoting factor 2, neurite outgrowth-promoting factor 2, retinoic acid inducible factor,)
• NCBI Gene ID: 4192
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21741
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

midkine interacts with:

• adaptor related protein complex 1 subunit mu 1
  AF4/FMR2 family member 4
  biorientation of chromosomes in cell division 1 like 1
  bromodomain containing 2
  chromodomain helicase DNA binding protein 9
  CWC22 spliceosome associated protein homolog
  CXXC finger protein 1
  erythrocyte membrane protein band 4.1 like 5
  F-box protein 7
  Josephin domain containing 2
  kelch repeat and BTB domain containing 7
  LDL receptor related protein 8
  midkine
  mitochondrial elongation factor 2
  mitogen-activated protein kinase 6
  MLLT3 super elongation complex subunit
  neural cell adhesion molecule 1
  NFKB activating protein
  NFU1 iron-sulfur cluster scaffold
  nidogen 1
  nidogen 2
  nitric oxide synthase 1 adaptor protein
  nuclear assembly factor 1 ribonucleoprotein
  nucleolin
  obscurin like cytoskeletal adaptor 1
  PBX homeobox 3
  peptidylprolyl isomerase G
  pinin, desmosome associated protein
  protein tyrosine phosphatase non-receptor type 9
  protein tyrosine phosphatase receptor type Z1
  ribonuclease P and MRP subunit p25
  ribosomal protein L18a
  ribosomal protein L36a like
  ribosomal protein S27a
  ribosome binding factor A
  serine/arginine repetitive matrix 2
  SET domain containing 1A, histone lysine methyltransferase
  signal transducer and activator of transcription 1
  SIN3 transcription regulator family member A
  sortilin related receptor 1
  SRSF protein kinase 2
  syndecan 1
  syndecan 3
  syndecan 4
  tetraspanin 1
  transcription elongation factor A2
  transglutaminase 1
  transmembrane p24 trafficking protein family member 8
  trinucleotide repeat containing 18
  tubulin alpha 1a
  tubulin beta 2B class IIb
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin conjugating enzyme E2 O
  upstream binding transcription factor
  zinc finger CCHC-type containing 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.