CIITA, class II major histocompatibility complex transactivator

CIITA, class II major histocompatibility complex transactivator

• This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

• Gene Synonyms (C2TA, CIITAIV, MHC2TA, NLRA, MHC class II transactivator, MHC class II transactivator type I, MHC class II transactivator type III, NLR family, acid domain containing, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing,)
• NCBI Gene ID: 4261
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0B4J1S1
  UNIPROT ID#>>P33076
  UNIPROT ID#>>A0A087X2I7
  UNIPROT ID#>>Q66X48
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

class II major histocompatibility complex transactivator interacts with:

• cullin 3
  E1A binding protein p400
  exportin 1
  H4 histone 16
  histone deacetylase 4
  histone deacetylase 5
  lysine acetyltransferase 2B
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  nuclear receptor coactivator 1
  nuclear transcription factor Y subunit beta
  peroxisome proliferator activated receptor gamma
  PML nuclear body scaffold
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 5
  protein kinase cAMP-activated catalytic subunit alpha
  regulatory factor X associated ankyrin containing protein
  regulatory factor X5
  RNA polymerase II subunit A
  SIN3 transcription regulator family member B
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  TATA-box binding protein
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 9
  tripartite motif containing 22
  ZXD family zinc finger C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.