PPARG, peroxisome proliferator activated receptor gamma

PPARG, peroxisome proliferator activated receptor gamma

• This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (peroxisome proliferator-activated receptor gamma, PPAR-gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated nuclear receptor gamma variant 1, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARG5, PPARgamma,)
• NCBI Gene ID: 5468
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q4W448
  UNIPROT ID#>>E9PFX5
  UNIPROT ID#>>D2KUA6
  UNIPROT ID#>>P37231
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peroxisome proliferator activated receptor gamma interacts with:

• acidic nuclear phosphoprotein 32 family member A
  actin related protein 2/3 complex subunit 2
  actin related protein 2/3 complex subunit 5
  adenylate cyclase 4
  ASH2 like, histone lysine methyltransferase complex subunit
  ATM interactor
  BAG cochaperone 2
  BAG cochaperone 5
  BCAS2 pre-mRNA processing factor
  bromodomain containing 8
  CCR4-NOT transcription complex subunit 1
  centrosomal protein 350
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 8
  COP9 signalosome subunit 5
  DEAD-box helicase 17
  DEAD-box helicase 18
  deoxynucleotidyltransferase terminal interacting protein 2
  DExD/H-box helicase 58
  DExD-box helicase 52
  DNA topoisomerase II beta
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member C7
  elongation factor Tu GTP binding domain containing 2
  endothelial differentiation related factor 1
  exportin 1
  FLYWCH family member 2
  forkhead box O1
  formin homology 2 domain containing 1
  G protein nucleolar 3
  GATA binding protein 5
  glutamate receptor interacting protein 1
  GRB10 interacting GYF protein 2
  growth arrest and DNA damage inducible gamma
  growth arrest and DNA-damage-inducible 45 beta
  GTP binding protein 4
  HEAT repeat containing 1
  helicase with zinc finger 2
  histone deacetylase 3
  histone deacetylase 4
  JAZF zinc finger 1
  jumonji domain containing 1C
  KH-type splicing regulatory protein
  Kruppel like factor 4
  leucine rich pentatricopeptide repeat containing
  ligand dependent nuclear receptor interacting factor 1
  LIM domain only 4
  lysine acetyltransferase 5
  lysine demethylase 4C
  macroH2A.1 histone
  MAF bZIP transcription factor F
  malignant fibrous histiocytoma amplified sequence 1
  mediator complex subunit 1
  mediator complex subunit 14
  mediator complex subunit 24
  MIF4G domain containing
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 1
  N-acetyltransferase 10
  NOP14 nucleolar protein
  NOP58 ribonucleoprotein
  nuclear factor, erythroid 2 like 3
  nuclear receptor binding SET domain protein 1
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 3
  nuclear receptor coactivator 4
  nuclear receptor coactivator 6
  nuclear receptor corepressor 1
  nuclear receptor co-repressor 1
  nuclear receptor corepressor 2
  nuclear receptor interacting protein 1
  nuclear receptor subfamily 0 group B member 2
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  nuclear receptor subfamily 2 group E member 3
  nucleoporin 93
  p21 (RAC1) activated kinase 4
  PAX interacting protein 1
  peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
  peroxisome proliferator activated receptor gamma
  peroxisome proliferator activated receptor gamma
  POF1B actin binding protein
  polybromo 1
  potassium channel tetramerization domain containing 13
  PPARG coactivator 1 alpha
  PPARG coactivator 1 beta
  prohibitin 2
  prospero homeobox 1
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, non-ATPase 11
  protein disulfide isomerase family A member 2
  protein inhibitor of activated STAT 1
  protein kinase AMP-activated catalytic subunit alpha 1
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase C alpha
  protein phosphatase with EF-hand domain 2
  protein phosphatase, Mg2+/Mn2+ dependent 1B
  RAD50 double strand break repair protein
  RAD54 like 2
  RAN binding protein 3
  RAN binding protein 9
  RB binding protein 5, histone lysine methyltransferase complex subunit
  RB transcriptional corepressor 1
  regulatory factor X5
  RELA proto-oncogene, NF-kB subunit
  replication protein A2
  retinoic acid receptor alpha
  retinoid X receptor alpha
  retinoid X receptor alpha
  retinoid X receptor beta
  retinoid X receptor gamma
  ribosomal L1 domain containing 1
  ribosomal protein L7a
  ribosomal protein L9
  ribosomal protein S3
  ribosomal protein S4 X-linked
  ribosomal protein S8
  ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
  RNA polymerase I and III subunit C
  roundabout guidance receptor 4
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  S100 calcium binding protein A9
  scaffold attachment factor B2
  selenoprotein K
  selenoprotein S
  serine and arginine rich splicing factor 1
  SH3 domain binding glutamate rich protein like
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 6
  sirtuin 1
  SMAD specific E3 ubiquitin protein ligase 1
  Sp1 transcription factor
  splicing factor 3b subunit 3
  splicing factor proline and glutamine rich
  STIP1 homology and U-box containing protein 1
  supervillin
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
  synaptotagmin 1
  talin 1
  t-complex 1
  thyroid hormone receptor interactor 4
  TNFAIP3 interacting protein 2
  transcription factor 4
  transcription factor AP-2 alpha
  transition protein 1
  tripartite motif containing 24
  tripartite motif containing 28
  Tu translation elongation factor, mitochondrial
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  U2 snRNP associated SURP domain containing
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 7
  UTP14A small subunit processome component
  valosin containing protein
  vitamin D receptor
  VPS29 retromer complex component
  X-ray repair cross complementing 5
  zinc finger and BTB domain containing 20
  zinc finger and BTB domain containing 3
  zinc finger and BTB domain containing 5
  zinc finger and BTB domain containing 9
  zinc finger and SCAN domain containing 1
  zinc finger CCCH-type containing, antiviral 1
  zinc finger HIT-type containing 3
  zinc finger protein 496

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.