AFDN, afadin, adherens junction formation factor

AFDN, afadin, adherens junction formation factor

• This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]

• Gene Synonyms (AF6, MLL-AF6, MLLT4, l-afadin, afadin, ALL1-fused gene from chromosome 6 protein, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4, protein AF-6,)
• NCBI Gene ID: 4301
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P55196
  UNIPROT ID#>>G1UI22
  UNIPROT ID#>>J3KN01
  UNIPROT ID#>>A8MQ02
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

afadin, adherens junction formation factor interacts with:

• ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  ariadne RBR E3 ubiquitin protein ligase 1
  BICD cargo adaptor 2
  chibby family member 1, beta catenin antagonist
  choline/ethanolamine phosphotransferase 1
  coiled-coil domain containing 8
  copine 2
  cullin 7
  cyclin dependent kinase 16
  DDB1 and CUL4 associated factor 15
  DENN domain containing 1A
  doublecortin like kinase 1
  eukaryotic translation initiation factor 4E family member 2
  F11 receptor
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  family with sequence similarity 53 member C
  fucose mutarotase
  GRB10 interacting GYF protein 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  kelch domain containing 3
  kinase suppressor of ras 1
  kinesin family member 13B
  large tumor suppressor kinase 2
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat containing G protein-coupled receptor 4
  LIM domain and actin binding 1
  membrane associated guanylate kinase, WW and PDZ domain containing 1
  microtubule associated scaffold protein 2
  mitochondrial ribosomal protein S11
  muscle and microspikes RAS
  muscle RAS oncogene homolog
  MYC proto-oncogene, bHLH transcription factor
  N-alpha-acetyltransferase 38, NatC auxiliary subunit
  NCK adaptor protein 2
  nectin cell adhesion molecule 1
  nectin cell adhesion molecule 2
  nectin cell adhesion molecule 3
  nectin cell adhesion molecule 4
  neurexin 1
  neurexin 2
  neurexin 3
  neurotrophic receptor tyrosine kinase 1
  notch receptor 2
  NRAS proto-oncogene, GTPase
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 35
  obscurin like cytoskeletal adaptor 1
  parkin RBR E3 ubiquitin protein ligase
  potassium channel tetramerization domain containing 3
  profilin 1
  protein interacting with PRKCA 1
  protein tyrosine phosphatase receptor type U
  RAB3A interacting protein
  ral guanine nucleotide dissociation stimulator
  RAP1 GTPase activating protein
  RAP1A, member of RAS oncogene family
  RAP2A, member of RAS oncogene family
  Ras and Rab interactor 1
  Ras like without CAAX 1
  Ras like without CAAX 2
  RAS related
  RAS related 2
  ring finger protein 146
  ring finger protein 4
  serine and arginine rich splicing factor 12
  SH3 and PX domains 2A
  signal induced proliferation associated 1 like 1
  sirtuin 7
  SLIT-ROBO Rho GTPase activating protein 2
  sorbin and SH3 domain containing 1
  sorbin and SH3 domain containing 2
  SSX family member 2 interacting protein
  suppressor of cytokine signaling 6
  synapse defective Rho GTPase homolog 1
  TBC1 domain family member 25
  testis associated actin remodelling kinase 2
  tight junction protein 1
  transmembrane protein 184A
  tripartite motif containing 25
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 9 X-linked
  vascular cell adhesion molecule 1
  zinc finger and BTB domain containing 21
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.