YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

YWHAG, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

• This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

• Gene Synonyms (14-3-3 protein gamma, KCIP-1, protein kinase C inhibitor protein 1, protein phosphatase 1, regulatory subunit 170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, 14-3-3GAMMA, EIEE56, PPP1R170,)
• NCBI Gene ID: 7532
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P61981
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma interacts with:

• AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  A-kinase anchoring protein 13
  AKT1 substrate 1
  angiomotin
  ANKHD1-EIF4EBP3 readthrough
  ankyrin repeat and sterile alpha motif domain containing 1A
  ankyrin repeat domain 55
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  apoptotic chromatin condensation inducer 1
  autophagy related 16 like 1
  BAG cochaperone 3
  BAR/IMD domain containing adaptor protein 2
  BAR/IMD domain containing adaptor protein 2 like 1
  BCL2 associated transcription factor 1
  BCL2 like 14
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bromodomain containing 1
  calcium/calmodulin dependent protein kinase kinase 1
  cell division cycle associated 7
  centromere protein E
  centromere protein J
  centrosomal protein 170
  centrosomal protein 250
  centrosomal protein 89
  centrosomal protein 95
  chaperonin containing TCP1 subunit 2
  chromatin assembly factor 1 subunit A
  chromobox 4
  cilia and flagella associated protein 20
  cingulin
  cingulin like 1
  clathrin interactor 1
  cleavage and polyadenylation specific factor 3
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  copper chaperone for superoxide dismutase
  CREB regulated transcription coactivator 1
  CREB regulated transcription coactivator 2
  CREB regulated transcription coactivator 3
  cullin 3
  cullin 7
  cyclin Y
  cytoplasmic FMR1 interacting protein 2
  cytoplasmic linker associated protein 1
  cytoskeleton associated protein 2
  DDB1 and CUL4 associated factor 7
  DEAD-box helicase 17
  DEAD-box helicase 27
  decapping mRNA 1A
  dedicator of cytokinesis 7
  DENN domain containing 4A
  denticleless E3 ubiquitin protein ligase homolog
  developmental pluripotency-associated 3
  DExD-box helicase 39B
  diablo IAP-binding mitochondrial protein
  DISC1 scaffold protein
  dual specificity phosphatase 16
  ELKS/RAB6-interacting/CAST family member 1
  elongation factor Tu GTP binding domain containing 2
  EMAP like 3
  enhancer of mRNA decapping 3
  epsin 2
  erythrocyte membrane protein band 4.1 like 3
  exonuclease 1
  family with sequence similarity 13 member B
  family with sequence similarity 163 member A
  family with sequence similarity 189 member A2
  family with sequence similarity 53 member C
  Fas associated factor 1
  F-box and WD repeat domain containing 11
  F-box protein 6
  FERM domain containing 5
  FERM domain containing 6
  FERM, ARH/RhoGEF and pleckstrin domain protein 2
  FRY like transcription coactivator
  FYVE, RhoGEF and PH domain containing 6
  GIT ArfGAP 1
  GIT ArfGAP 2
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  GTP binding protein 4
  H3 clustered histone 1
  heat shock protein family B (small) member 6
  HECT domain E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 7
  huntingtin
  inositol polyphosphate-5-phosphatase E
  insulin receptor substrate 2
  insulin receptor substrate 4
  isoleucyl-tRNA synthetase 2, mitochondrial
  janus kinase and microtubule interacting protein 1
  KIAA0408
  KIAA0930
  kinase suppressor of ras 1
  kinesin family member 1B
  kinesin family member 1C
  kinesin family member 23
  kinesin light chain 2
  kinesin light chain 3
  kinesin light chain 4
  KN motif and ankyrin repeat domains 1
  La ribonucleoprotein 1, translational regulator
  large tumor suppressor kinase 2
  lebercilin LCA5
  leucine rich repeat kinase 2
  leucine rich repeats and calponin homology domain containing 3
  LIM domain and actin binding 1
  lipolysis stimulated lipoprotein receptor
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  lysine acetyltransferase 5
  mab-21 like 2
  mago homolog B, exon junction complex subunit
  MAPK associated protein 1
  methylphosphate capping enzyme
  mex-3 RNA binding family member B
  MICAL like 1
  mitochondrial elongation factor 1
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 20
  M-phase phosphoprotein 9
  MSL complex subunit 2
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  MYC binding protein 2
  myosin phosphatase Rho interacting protein
  myotubularin related protein 4
  NAD kinase
  NCK associated protein 1
  NCK interacting protein with SH3 domain
  NEDD4 binding protein 3
  NEDD4 like E3 ubiquitin protein ligase
  NHS like 2
  NKD inhibitor of WNT signaling pathway 2
  nuclear FMR1 interacting protein 2
  nucleolar and coiled-body phosphoprotein 1
  nudE neurodevelopment protein 1
  nudE neurodevelopment protein 1 like 1
  NUMB like endocytic adaptor protein
  optineurin
  oxysterol binding protein like 3
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 6
  par-3 family cell polarity regulator
  par-3 family cell polarity regulator beta
  peptidylprolyl isomerase E
  peptidylprolyl isomerase G
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phospholipase A2 group XIIA
  PIH1 domain containing 1
  pleckstrin homology and RhoGEF domain containing G5
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A5
  pleckstrin homology like domain family B member 2
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(U) binding splicing factor 60
  potassium two pore domain channel subfamily K member 15
  potassium two pore domain channel subfamily K member 9
  PPFIA binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 38B
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 4B
  protection of telomeres 1
  protein arginine methyltransferase 5
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  protein tyrosine phosphatase domain containing 1
  PTEN induced kinase 1
  PTPRF interacting protein alpha 1
  RAB guanine nucleotide exchange factor 1
  RAB11 family interacting protein 1
  RAB11 family interacting protein 2
  RAB11 family interacting protein 5
  RAB11A, member RAS oncogene family
  rabaptin, RAB GTPase binding effector protein 1
  Rac GTPase activating protein 1
  Rac/Cdc42 guanine nucleotide exchange factor 6
  Ral GEF with PH domain and SH3 binding motif 2
  Rap guanine nucleotide exchange factor 6
  Ras and Rab interactor 1
  Ras association domain family member 2
  Ras association domain family member 8
  RAS protein activator like 2
  receptor accessory protein 1
  RecQ like helicase 4
  regulator of microtubule dynamics 3
  retinoic acid induced 14
  RHO family interacting cell polarization regulator 2
  Rho guanine nucleotide exchange factor 7
  Rho/Rac guanine nucleotide exchange factor 2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 31
  RNA binding motif protein 7
  RNA binding protein with serine rich domain 1
  SAM domain, SH3 domain and nuclear localization signals 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 10
  serine/arginine repetitive matrix 2
  SH3 binding domain protein 5 like
  SH3 domain binding protein 4
  SH3KBP1 binding protein 1
  SHC binding and spindle associated 1
  slingshot protein phosphatase 1
  SLIT-ROBO Rho GTPase activating protein 2
  small nuclear ribonucleoprotein U5 subunit 200
  smoothelin like 2
  SNF2 histone linker PHD RING helicase
  sorting nexin 24
  speckle type BTB/POZ protein
  spermatogenesis associated 13
  splicing factor 3b subunit 3
  sterile alpha motif domain containing 4A
  sterile alpha motif domain containing 4B
  SUMO interacting motifs containing 1
  suppressor of cytokine signaling 6
  synaptopodin
  synaptopodin 2
  TATA-box binding protein associated factor 15
  TBC1 domain family member 1
  TBC1 domain family member 4
  tensin 2
  TERF1 interacting nuclear factor 2
  testis expressed 33
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thioredoxin domain containing 5
  thymocyte expressed, positive selection associated 1
  thyroid hormone receptor associated protein 3
  tight junction protein 2
  TNF receptor superfamily member 10a
  TNF superfamily member 13b
  TNFAIP3 interacting protein 2
  transcription factor EB
  transformer 2 alpha homolog
  transmembrane protein 102
  tripartite motif containing 32
  tubulin beta 4A class IVa
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase non receptor 1
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 R2
  ubiquitin family domain containing 1
  ubiquitin specific peptidase 37
  ubiquitin specific peptidase 8
  ubiquitin specific peptidase 8
  unk zinc finger
  vir like m6A methyltransferase associated
  WD repeat domain 62
  WNK lysine deficient protein kinase 1
  WW and C2 domain containing 1
  WW domain containing transcription regulator 1
  WW domain containing transcription regulator 1
  Yes1 associated transcriptional regulator
  yes-associated protein 1
  ZFP36 ring finger protein
  zinc finger and BTB domain containing 21
  zinc finger protein 397

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.