NFKB2, nuclear factor kappa B subunit 2

NFKB2, nuclear factor kappa B subunit 2

• This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

• Gene Synonyms (CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52, nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, NFKB, p52/p100 subunit, lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B, subunit 2, nuclear factor NF-kappa-B p52 subunit, nuclear factor of Kappa light chain gene enhancer in B cells 2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), oncogene Lyt-10, transcription factor NFKB2,)
• NCBI Gene ID: 4791
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q00653
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear factor kappa B subunit 2 interacts with:

• ankyrin repeat and SOCS box containing 2
  ATPase family AAA domain containing 3B
  autophagy related 16 like 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  COMM domain containing 2
  copper metabolism domain containing 1
  cullin 4A
  cullin 4B
  DEF6 guanine nucleotide exchange factor
  double PHD fingers 2
  exportin 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  histone deacetylase 4
  histone deacetylase 5
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  kinesin light chain 3
  metadherin
  mitogen-activated protein kinase kinase kinase 14
  NFKB inhibitor alpha
  NFKB inhibitor beta
  NFKB inhibitor delta
  NFKB inhibitor epsilon
  NFKB inhibitor zeta
  NFKB repressing factor
  nuclear factor kappa B subunit 2
  nuclear RNA export factor 1
  peptidyl arginine deiminase 3
  proteasome 26S subunit, non-ATPase 11
  protein phosphatase 1 regulatory subunit 13 like
  RAB11 family interacting protein 5
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  ribosomal protein L30
  ribosomal protein L6
  ribosomal protein S13
  SEC16 homolog A, endoplasmic reticulum export factor
  SEC61 translocon subunit alpha 1
  signal transducer and activator of transcription 3
  Sp1 transcription factor
  TANK binding kinase 1
  TNF alpha induced protein 3
  TNF superfamily member 13b
  TNFAIP3 interacting protein 2
  tumor susceptibility 101
  ubiquitin specific peptidase 2
  valosin containing protein
  vitamin D receptor
  zinc fingers and homeoboxes 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.