NFKBIA, NFKB inhibitor alpha

NFKBIA, NFKB inhibitor alpha

• This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

• Gene Synonyms (EDAID2, IKBA, MAD-3, NFKBI, NF-kappa-B inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, ikB-alpha, major histocompatibility complex enhancer-binding protein MAD3, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha,)
• NCBI Gene ID: 4792
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P25963
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NFKB inhibitor alpha interacts with:

• acidic residue methyltransferase 1
  ankyrin repeat and SOCS box containing 2
  ankyrin repeat domain 27
  aurora kinase A
  AVL9 cell migration associated
  axin interactor, dorsalization associated
  BCL10 immune signaling adaptor
  beta-transducin repeat containing E3 ubiquitin protein ligase
  ChaC glutathione specific gamma-glutamylcyclotransferase 2
  COP9 signalosome subunit 2
  COP9 signalosome subunit 3
  COP9 signalosome subunit 8
  copper metabolism domain containing 1
  CUE domain containing 1
  cullin 1
  cytosolic thiouridylase subunit 2
  DDB1 and CUL4 associated factor 6
  density regulated re-initiation and release factor
  DnaJ heat shock protein family (Hsp40) member A3
  dynein light chain LC8-type 1
  egl-9 family hypoxia inducible factor 3
  ELKS/RAB6-interacting/CAST family member 1
  elongator complex protein 1
  enkurin domain containing 1
  eukaryotic translation initiation factor 2 alpha kinase 2
  exportin 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 8
  G3BP stress granule assembly factor 2
  glucosamine-phosphate N-acetyltransferase 1
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  hypoxia inducible factor 1 subunit alpha inhibitor
  IKAROS family zinc finger 4
  inhibitor of kappaB kinase gamma
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  MALT1 paracaspase
  MCTS1 re-initiation and release factor
  mediator complex subunit 19
  mediator complex subunit 31
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 7
  MTOR associated protein, eak-7 homolog
  NFKB inhibitor beta
  NFKB inhibitor epsilon
  NFKB inhibitor interacting Ras like 1
  NFKB inhibitor interacting Ras like 2
  NPL4 homolog, ubiquitin recognition factor
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxoglutarate dehydrogenase L
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoribosyl transferase domain containing 1
  pirin
  plastin 1
  POM121 transmembrane nucleoporin
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 4
  proteasome 26S subunit, non-ATPase 3
  protein kinase C alpha
  protein kinase C iota
  protein phosphatase 1 regulatory subunit 9A
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 13
  RAS p21 protein activator 1
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  Rho GTPase activating protein 39
  ribosomal protein S3
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A3
  ring finger protein 115
  ring finger protein 121
  ring finger protein 183
  RNA polymerase II subunit A
  RNA polymerase II subunit C
  RNA polymerase II subunit J
  RNA polymerase mitochondrial
  RWD domain containing 3
  secernin 2
  signal transducer and activator of transcription 1
  small ubiquitin like modifier 1
  small ubiquitin like modifier 4
  sperm antigen with calponin homology and coiled-coil domains 1 like
  S-phase kinase associated protein 1
  spindle apparatus coiled-coil protein 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppression of tumorigenicity 7
  suppressor of cytokine signaling 3
  TANK binding kinase 1
  TBC1 domain family member 24
  TCL1 family AKT coactivator A
  TNF superfamily member 11
  TNFAIP3 interacting protein 2
  transcription elongation factor A1
  transglutaminase 2
  tubulin alpha 1b
  tubulin folding cofactor E
  tumor necrosis factor
  tumor protein p53
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L3
  ubiquitin family domain containing 1
  ubiquitin recognition factor in ER associated degradation 1
  valosin containing protein
  YES proto-oncogene 1, Src family tyrosine kinase
  zinc finger and BTB domain containing 7A
  zinc finger protein 212

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.