CPSF3, cleavage and polyadenylation specific factor 3

CPSF3, cleavage and polyadenylation specific factor 3

• This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

• Gene Synonyms (cleavage and polyadenylation specificity factor subunit 3, cleavage and polyadenylation specific factor 3, 73kDa, mRNA 3'-end-processing endonuclease CPSF-73, CPSF-73, CPSF73,)
• NCBI Gene ID: 51692
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G5E9W3
  UNIPROT ID#>>Q9UKF6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cleavage and polyadenylation specific factor 3 interacts with:

• activation induced cytidine deaminase
  autophagy related 16 like 1
  cell division cycle 73
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 4 like
  factor interacting with PAPOLA and CPSF1
  F-box and WD repeat domain containing 7
  ISY1 splicing factor homolog
  ISY1-RAB43 readthrough
  lysine demethylase 1B
  pleckstrin homology domain containing A4
  prolyl 3-hydroxylase 1
  RAD18 E3 ubiquitin protein ligase
  ring finger protein 31
  RNA polymerase I subunit E
  S-adenosylhomocysteine hydrolase-like 1
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  terminal uridylyl transferase 1, U6 snRNA-specific
  TNFAIP3 interacting protein 2
  ubiquitin protein ligase E3D
  WD repeat domain 33
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.