RAD18, RAD18 E3 ubiquitin protein ligase

RAD18, RAD18 E3 ubiquitin protein ligase

• The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

• Gene Synonyms (RNF73, E3 ubiquitin-protein ligase RAD18, RAD18 homolog, RAD18, S. cerevisiae, homolog, RING finger protein 73, RING-type E3 ubiquitin transferase RAD18, hHR18, hRAD18, postreplication repair protein RAD18, postreplication repair protein hRAD18p,)
• NCBI Gene ID: 56852
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NS91
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RAD18 E3 ubiquitin protein ligase interacts with:

• actin beta like 2
  actin filament associated protein 1
  arrestin domain containing 3
  ATP synthase mitochondrial F1 complex assembly factor 1
  BUD13 homolog
  caveolae associated protein 1
  cell division cycle 73
  ceramide kinase
  chromosome alignment maintaining phosphoprotein 1
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 97
  CWC22 spliceosome associated protein homolog
  DEAD-box helicase 54
  DNA polymerase nu
  exportin 5
  factor interacting with PAPOLA and CPSF1
  family with sequence similarity 133 member B
  H2A clustered histone 1
  H2A.W histone
  H2A.Z variant histone 2
  H2B.U histone 1
  H3 clustered histone 15
  HDGF like 2
  junctophilin 4
  kelch domain containing 3
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leukocyte receptor cluster member 8
  mitochondrial ribosomal protein S9
  mixed lineage kinase domain like pseudokinase
  myosin heavy chain 14
  myosin light chain 12B
  NFKB activating protein
  nuclear receptor coactivator 5
  PAX3 and PAX7 binding protein 1
  PEST proteolytic signal containing nuclear protein
  PHD finger protein 5A
  pleckstrin homology domain containing A4
  polycomb group ring finger 6
  pre-mRNA processing factor 38A
  protein phosphatase 1 regulatory subunit 9B
  RAD18 E3 ubiquitin protein ligase
  RAD9-HUS1-RAD1 interacting nuclear orphan 1
  RBMX like 1
  RNA binding motif protein 15
  RNA binding motif protein 17
  RNA binding motif protein 26
  RNA binding motif protein 42
  serine and arginine rich splicing factor 12
  SLIT-ROBO Rho GTPase activating protein 1
  Smad nuclear interacting protein 1
  small nuclear ribonucleoprotein U11/U12 subunit 48
  SMC5-SMC6 complex localization factor 1
  SMC5-SMC6 complex localization factor 1
  SNF2 histone linker PHD RING helicase
  SNF2 histone linker PHD RING helicase
  splicing factor 3b subunit 5
  SprT-like N-terminal domain
  SPT2 chromatin protein domain containing 1
  SR-related CTD associated factor 1
  SR-related CTD associated factor 4
  structural maintenance of chromosomes 6
  structural maintenance of chromosomes 6
  SURP and G-patch domain containing 1
  target of EGR1, exonuclease
  transcription elongation factor A N-terminal and central domain containing 2
  translocase of inner mitochondrial membrane 50
  tripartite motif containing 8
  tubulin alpha 1c
  WD repeat domain 61
  WD repeat domain 82
  WRN helicase interacting protein 1
  ZFP41 zinc finger protein
  zinc finger CCCH-type containing 18
  zinc finger protein 501

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.