PLCG2, phospholipase C gamma 2

PLCG2, phospholipase C gamma 2

• The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

• Gene Synonyms (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, phosphoinositide phospholipase C-gamma-2, phospholipase C, gamma 2 (phosphatidylinositol-specific), phospholipase C-IV, APLAID, FCAS3, PLC-IV, PLC-gamma-2,)
• NCBI Gene ID: 5336
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16885
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phospholipase C gamma 2 interacts with:

• ankyrin repeat and SOCS box containing 9
  autophagy related 16 like 1
  B cell linker
  c-src tyrosine kinase
  dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  GA binding protein transcription factor subunit beta 2
  GRB2 associated binding protein 2
  KH RNA binding domain containing, signal transduction associated 1
  Lck interacting transmembrane adaptor 1
  LIM homeobox 8
  linker for activation of T cells
  linker for activation of T cells family member 2
  phosphoinositide-3-kinase adaptor protein 1
  phospholipase C gamma 2
  phospholipase D1
  pleckstrin homology domain containing A4
  plexin B1
  potassium channel tetramerization domain containing 17
  proteasome 26S subunit, non-ATPase 3
  protein kinase C alpha
  protein kinase D1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  PTTG1 regulator of sister chromatid separation, securin
  RAD54 homolog B
  ralA binding protein 1
  retrotransposon Gag like 10
  SET domain containing 9
  SH3 domain binding protein 2
  SHC adaptor protein 1
  spleen associated tyrosine kinase
  tec protein tyrosine kinase
  tripartite motif containing 25
  tumor protein p53
  twist family bHLH transcription factor 2
  vav guanine nucleotide exchange factor 1
  vir like m6A methyltransferase associated
  zinc finger protein 512B
  zinc finger with KRAB and SCAN domains 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.