PLP1, proteolipid protein 1

PLP1, proteolipid protein 1

• This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]

• Gene Synonyms (myelin proteolipid protein, lipophilin, major myelin proteolipid protein, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2,)
• NCBI Gene ID: 5354
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z4D4
  UNIPROT ID#>>P60201
  UNIPROT ID#>>B4DI30
  UNIPROT ID#>>A8K9L3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteolipid protein 1 interacts with:

• adhesion G protein-coupled receptor G3
  ADP ribosylation factor like GTPase 13B
  aquaporin 10
  BCL2 like 13
  calneuron 1
  cAMP responsive element binding protein 3
  cAMP responsive element binding protein 3 like 1
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase
  claudin 2
  claudin 20
  C-type lectin domain family 2 member D
  cytochrome b-245 chaperone 1
  dysferlin
  early endosome antigen 1
  ectodysplasin A2 receptor
  ELOVL fatty acid elongase 4
  ERGIC and golgi 3
  family with sequence similarity 209 member A
  family with sequence similarity 241 member A
  Fc receptor like 2
  FGFR1 oncogene partner 2
  fibronectin type III domain containing 9
  G protein-coupled receptor 61
  glutamine amidotransferase like class 1 domain containing 1
  huntingtin
  immediate early response 3 interacting protein 1
  interferon induced transmembrane protein 3
  jagunal homolog 1
  junctophilin 1
  leptin receptor overlapping transcript like 1
  leucine twenty homeobox
  LHFPL tetraspan subfamily member 5
  membrane spanning 4-domains A4A
  mitochondrial fission factor
  mitochondrial translational initiation factor 3
  myeloid associated differentiation marker
  peptidase inhibitor 16
  phosphatidylinositol glycan anchor biosynthesis class P
  protein tyrosine phosphatase receptor type N
  receptor accessory protein 5
  receptor accessory protein 6
  regulator of microtubule dynamics 3
  RELT like 2
  reticulon 2
  ring finger protein 114
  ring finger protein 24
  sarcolemma associated protein
  small integral membrane protein 3
  solute carrier family 1 member 5
  solute carrier family 10 member 6
  solute carrier family 16 member 2
  solute carrier family 18 member A1
  solute carrier family 26 member 6
  solute carrier family 35 member E2A
  solute carrier family 35 member E3
  solute carrier family 41 member 3
  sphingolipid transporter 3 (putative)
  striatin
  striatin 4
  striatin interacting protein 1
  suppressor of IKBKE 1
  sushi domain containing 3
  syntaxin 1A
  syntaxin 4
  transmembrane protein 106C
  transmembrane protein 14B
  transmembrane protein 182
  transmembrane protein 242
  transmembrane protein 243
  transmembrane protein 254
  transmembrane protein 31
  transmembrane protein 45B
  transmembrane protein 52B
  transmembrane protein 97
  transmembrane serine protease 2
  uroplakin 2
  vesicle amine transport 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.