PLP2, proteolipid protein 2

PLP2, proteolipid protein 2

• This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

• Gene Synonyms (proteolipid protein 2, A4 differentiation-dependent protein, differentiation-dependent protein A4, intestinal membrane A4 protein, proteolipid protein 2 (colonic epithelium-enriched), A4, A4LSB,)
• NCBI Gene ID: 5355
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q04941
  UNIPROT ID#>>A0A024QYW3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteolipid protein 2 interacts with:

• ADP ribosylation factor interacting protein 2
  aspartyl-tRNA synthetase 2, mitochondrial
  B cell receptor associated protein 31
  cAMP responsive element binding protein 3 like 1
  CD2 cytoplasmic tail binding protein 2
  centrosomal protein 290
  ceramide synthase 4
  claudin 5
  complexin 4
  crumbs cell polarity complex component 3
  cytochrome b reductase 1
  cytochrome b-245 chaperone 1
  cytosolic iron-sulfur assembly component 2A
  DLG associated protein 4
  DnaJ heat shock protein family (Hsp40) member C1
  EBP cholestenol delta-isomerase
  elongator complex protein 1
  ELOVL fatty acid elongase 5
  family with sequence similarity 209 member A
  family with sequence similarity 210 member B
  fetal and adult testis expressed 1
  fibronectin type III domain containing 9
  G protein-coupled receptor 151
  glutathione peroxidase 8 (putative)
  heat shock factor binding protein 1 like 1
  hydroxysteroid 17-beta dehydrogenase 11
  hydroxysteroid 17-beta dehydrogenase 13
  KASH domain containing 5
  L antigen family member 3
  laccase domain containing 1
  leucine rich repeat containing 4C
  LHFPL tetraspan subfamily member 1
  LHFPL tetraspan subfamily member 5
  mitochondrial ribosomal protein L30
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein L57
  mitochondrial ribosomal protein L9
  NDRG family member 4
  NudC domain containing 2
  PDZK1 interacting protein 1
  pentatricopeptide repeat domain 3
  phosphatidylinositol glycan anchor biosynthesis class P
  prostaglandin E synthase
  prostate stem cell antigen
  proteolipid protein 2
  proton activated chloride channel 1
  PVR cell adhesion molecule
  receptor accessory protein 4
  reticulophagy regulator family member 3
  ring finger protein 4
  ring finger protein 5
  S100 calcium binding protein A11
  secretion associated Ras related GTPase 1A
  sex hormone binding globulin
  shugoshin 2
  sialophorin
  sideroflexin 3
  sodium voltage-gated channel beta subunit 3
  solute carrier family 12 member 4
  solute carrier family 14 member 2
  solute carrier family 18 member A1
  solute carrier family 2 member 13
  solute carrier family 35 member C2
  SPG21 abhydrolase domain containing, maspardin
  sphingosine-1-phosphate lyase 1
  STT3 oligosaccharyltransferase complex catalytic subunit B
  synaptotagmin binding cytoplasmic RNA interacting protein
  THAP domain containing 4
  thioredoxin related transmembrane protein 2
  transmembrane 4 L six family member 19
  transmembrane protein 14B
  transmembrane protein 31
  transmembrane protein 51
  transmembrane protein 79
  transmembrane serine protease 2
  tripartite motif containing 25
  vitamin K epoxide reductase complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.