PSMD9, proteasome 26S subunit, non-ATPase 9

PSMD9, proteasome 26S subunit, non-ATPase 9

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

• Gene Synonyms (26S proteasome non-ATPase regulatory subunit 9, 26S proteasome regulatory subunit p27, homolog of rat Bridge 1, proteasome (prosome, macropain) 26S subunit, non-ATPase, 9, proteasome 26S non-ATPase regulatory subunit 9, Rpn4, p27,)
• NCBI Gene ID: 5715
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00233
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, non-ATPase 9 interacts with:

• adenosylhomocysteinase like 1
  angiomotin like 2
  BAG cochaperone 3
  BTG3 associated nuclear protein
  caveolae associated protein 1
  CD2 cytoplasmic tail binding protein 2
  CDV3 homolog
  centrosomal protein 85 like
  clock circadian regulator
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 136
  coiled-coil domain containing 40
  coiled-coil domain containing 93
  complexin 1
  DAZ interacting zinc finger protein 3
  destrin, actin depolymerizing factor
  EARP complex and GARP complex interacting protein 1
  elongation factor Tu GTP binding domain containing 2
  epididymal sperm binding protein 1
  ERI1 exoribonuclease family member 3
  GIT ArfGAP 2
  glucosamine-6-phosphate deaminase 1
  glycogen phosphorylase L
  golgin A5
  GRIP1 associated protein 1
  HAUS augmin like complex subunit 6
  high mobility group 20A
  inositol-3-phosphate synthase 1
  lysine demethylase 1A
  NCK associated protein 5 like
  NCK interacting protein with SH3 domain
  NudC domain containing 2
  NUF2 component of NDC80 kinetochore complex
  Opa interacting protein 5
  PHD finger protein 21A
  pleckstrin homology domain containing A4
  pleckstrin homology like domain family B member 3
  poly(A) binding protein cytoplasmic 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 6
  protein kinase N3
  RAB GTPase activating protein 1 like
  RAB guanine nucleotide exchange factor 1
  rabaptin, RAB GTPase binding effector protein 1
  Ras and Rab interactor 3
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 1A
  REST corepressor 1
  SEM1 26S proteasome complex subunit
  sestrin 2
  S-phase kinase associated protein 2
  TCF3 fusion partner
  THAP domain containing 11
  TNF receptor associated factor 2
  TNFAIP3 interacting protein 2
  transcription factor 3
  tripartite motif containing 14
  tripartite motif containing 39
  tripartite motif containing 42
  tropomodulin 3
  tuftelin 1
  tumor necrosis factor
  twinfilin actin binding protein 2
  ubiquitin conjugating enzyme E2 I
  VPS50 subunit of EARP/GARPII complex
  VPS53 subunit of GARP complex
  WW domain containing oxidoreductase
  X-prolyl aminopeptidase 1
  YEATS domain containing 4
  YY1 transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.