PTN, pleiotrophin

PTN, pleiotrophin

• The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

• Gene Synonyms (pleiotrophin, heparin affin regulatory protein, heparin-binding brain mitogen, heparin-binding growth factor 8, heparin-binding growth-associated molecule, heparin-binding neurite outgrowth promoting factor, heparin-binding neurite outgrowth-promoting factor 1, osteoblast-specific factor 1, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1), HARP, HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1,)
• NCBI Gene ID: 5764
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21246
  UNIPROT ID#>>A0A024R778
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pleiotrophin interacts with:

• ADP ribosylation factor like GTPase 15
  apolipoprotein B mRNA editing enzyme catalytic subunit 3G
  ariadne RBR E3 ubiquitin protein ligase 2
  BAG cochaperone 6
  BRCA2 and CDKN1A interacting protein
  BTB domain containing 2
  caspase activity and apoptosis inhibitor 1
  CDK5 regulatory subunit associated protein 2
  chromosome 11 open reading frame 58
  chromosome 7 open reading frame 25
  cysteine rich C-terminal 1
  cysteine rich with EGF like domains 1
  DnaJ heat shock protein family (Hsp40) member B11
  dual specificity phosphatase 12
  eukaryotic translation initiation factor 3 subunit F
  eva-1 homolog A, regulator of programmed cell death
  fasciculation and elongation protein zeta 1
  G protein-coupled receptor associated sorting protein 2
  GIPC PDZ domain containing family member 2
  glycine-N-acyltransferase
  growth arrest and DNA damage inducible gamma
  HGH1 homolog
  HSPB1 associated protein 1
  intersectin 2
  LUC7 like 2, pre-mRNA splicing factor
  MAD2L1 binding protein
  McKusick-Kaufman syndrome
  mitochondrial ribosomal protein L44
  MYC binding protein
  NIMA related kinase 6
  nucleosome assembly protein 1 like 5
  nudix hydrolase 21
  pleiotrophin
  plexin B2
  polyamine modulated factor 1
  protein inhibitor of activated STAT 4
  protein tyrosine phosphatase receptor type B
  protein tyrosine phosphatase receptor type S
  protein tyrosine phosphatase receptor type Z1
  Ras like without CAAX 1
  receptor for activated C kinase 1
  ribosomal protein lateral stalk subunit P1
  RNA binding motif protein 23
  signal sequence receptor subunit 1
  small G protein signaling modulator 2
  small glutamine rich tetratricopeptide repeat containing alpha
  solute carrier family 25 member 36
  spermidine/spermine N1-acetyltransferase 1
  spindlin 1
  SPT7 like, STAGA complex subunit gamma
  stanniocalcin 2
  syndecan 1
  syndecan 3
  synuclein alpha interacting protein
  tachykinin precursor 3
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  thioredoxin domain containing 9
  transforming growth factor beta regulator 4
  translocase of outer mitochondrial membrane 20
  TSC22 domain family member 1
  tumor protein p53 binding protein 2
  ubiquilin 1
  ubiquilin 4
  UTP3 small subunit processome component
  WAP four-disulfide core domain 2
  WASH complex subunit 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.