PTPRG, protein tyrosine phosphatase receptor type G

PTPRG, protein tyrosine phosphatase receptor type G

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (receptor-type tyrosine-protein phosphatase gamma, H_RG317H01.1, protein tyrosine phosphatase gamma, protein tyrosine phosphatase, receptor type, gamma polypeptide, receptor type protein tyrosine phosphatase gamma, receptor tyrosine phosphatase gamma, receptor-type protein phosphatase gamma, HPTPG, PTPG, R-PTP-GAMMA, RPTPG,)
• NCBI Gene ID: 5793
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23470
  UNIPROT ID#>>Q49A02
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase receptor type G interacts with:

• acyl-CoA binding domain containing 7
  CASK interacting protein 2
  CDC42 binding protein kinase beta
  centrosomal protein 89
  chloride channel CLIC like 1
  cyclin L2
  defensin beta 104A
  dihydrouridine synthase 4 like
  dual specificity phosphatase 22
  dual specificity phosphatase 23
  dual specificity phosphatase 26
  FCH and mu domain containing endocytic adaptor 2
  FERM, ARH/RhoGEF and pleckstrin domain protein 1
  forty-two-three domain containing 1
  G protein regulated inducer of neurite outgrowth 1
  gap junction protein beta 7
  heat shock protein family A (Hsp70) member 12A
  immediate early response 3 interacting protein 1
  mediator complex subunit 21
  neuropeptide B
  niban apoptosis regulator 2
  nicastrin
  phosphofurin acidic cluster sorting protein 1
  pleckstrin and Sec7 domain containing 3
  protein tyrosine phosphatase receptor type G
  ribosomal protein S15
  SEC24 homolog A, COPII coat complex component
  serpin family A member 12
  solute carrier family 39 member 10
  syndecan 1
  transmembrane protein 185A
  vir like m6A methyltransferase associated
  zinc finger protein 517

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.