RFX2, regulatory factor X2

RFX2, regulatory factor X2

• This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DNA-binding protein RFX2, HLA class II regulatory factor RFX2, regulatory factor X 2, regulatory factor X, 2 (influences HLA class II expression), trans-acting regulatory factor 2,)
• NCBI Gene ID: 5990
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48378
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

regulatory factor X2 interacts with:

• chromosome 1 open reading frame 94
  F-box and leucine rich repeat protein 3
  forkhead box J2
  forkhead box N4
  NFKB inhibitor delta
  protein inhibitor of activated STAT 2
  regulatory factor X2
  regulatory factor X4
  regulatory factor X6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.