SETMAR, SET domain and mariner transposase fusion gene

SETMAR, SET domain and mariner transposase fusion gene

• This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

• Gene Synonyms (histone-lysine N-methyltransferase SETMAR, SET domain and mariner transposase fusion gene-containing protein, SET domain and mariner transposase fusion protein, METNASE, Mar1,)
• NCBI Gene ID: 6419
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DND2
  UNIPROT ID#>>Q96H41
  UNIPROT ID#>>Q53H47
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SET domain and mariner transposase fusion gene interacts with:

• DNA topoisomerase II alpha
  double C2 domain alpha
  H3.5 histone
  IKAROS family zinc finger 3
  LEO1 homolog, Paf1/RNA polymerase II complex component
  N(alpha)-acetyltransferase 50, NatE catalytic subunit
  pre-mRNA processing factor 19
  senataxin
  SET domain and mariner transposase fusion gene
  X-ray repair cross complementing 4
  YJU2 splicing factor homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.