SPG7, SPG7 matrix AAA peptidase subunit, paraplegin

SPG7, SPG7 matrix AAA peptidase subunit, paraplegin

• This gene encodes a mitochondrial metalloprotease protein that is a member of the AAA family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. Mutations in this gene cause autosomal recessive spastic paraplegia 7. Two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2014]

• Gene Synonyms (paraplegin, SPG7, paraplegin matrix AAA peptidase subunit, cell matrix adhesion regulator, spastic paraplegia 7 (pure and complicated autosomal recessive), spastic paraplegia 7 protein, CAR, CMAR, PGN, SPG5C,)
• NCBI Gene ID: 6687
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UQ90
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SPG7 matrix AAA peptidase subunit, paraplegin interacts with:

• 5-hydroxytryptamine receptor 3C
  carboxypeptidase A5
  ceramide kinase
  cyclin D1 binding protein 1
  cysteine rich tail 1
  ER membrane protein complex subunit 2
  family with sequence similarity 174 member A
  Fas associated factor family member 2
  flotillin 1
  G protein-coupled receptor 55
  heat shock transcription factor 2 binding protein
  heterogeneous nuclear ribonucleoprotein R
  histone deacetylase 10
  integral membrane protein 2A
  jun B proto-oncogene
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-9
  keratin associated protein 4-12
  KH RNA binding domain containing, signal transduction associated 2
  kinesin family binding protein
  leucine zipper tumor suppressor 2
  ligand dependent nuclear receptor interacting factor 1
  lysophosphatidylcholine acyltransferase 4
  matrix AAA peptidase interacting protein 1
  microtubule associated scaffold protein 2
  NBPF member 19
  NDC80 kinetochore complex component
  notch 2 N-terminal like A
  PH domain containing endocytic trafficking adaptor 1
  pleckstrin homology domain containing A4
  PNMA family member 1
  proline-serine-threonine phosphatase interacting protein 1
  proteasome activator subunit 3
  RALY heterogeneous nuclear ribonucleoprotein
  ring finger protein 1
  RNA binding protein, mRNA processing factor
  SAM and SH3 domain containing 1
  sideroflexin 2
  solute carrier family 2 member 12
  spermatogenesis associated serine rich 1
  STAM binding protein
  stromal cell derived factor 4
  TPX2, microtubule-associated
  tripartite motif containing 28

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.