TAP2, transporter 2, ATP binding cassette subfamily B member

TAP2, transporter 2, ATP binding cassette subfamily B member

• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

• Gene Synonyms (antigen peptide transporter 2, ABC transporter, MHC 2, ATP-binding cassette, sub-family B (MDR/TAP), member 3, peptide supply factor 2, peptide transporter PSF2, peptide transporter involved in antigen processing 2, really interesting new gene 11 protein, transporter 2, ABC (ATP binding cassette), transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11,)
• NCBI Gene ID: 6891
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5JNW1
  UNIPROT ID#>>X5CMH5
  UNIPROT ID#>>Q03519
  UNIPROT ID#>>Q9UP03
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transporter 2, ATP binding cassette subfamily B member interacts with:

• atlastin GTPase 3
  ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
  CDC16 cell division cycle 16
  cytoskeleton associated protein 5
  microtubule associated serine/threonine kinase like
  pleckstrin homology domain containing A4
  proteasome assembly chaperone 3
  RNA binding motif protein 18
  solute carrier family 17 member 2
  TAP binding protein
  tectonic family member 2
  tectonic family member 3
  timeless circadian clock 1
  TOX high mobility group box family member 4
  transmembrane and coiled-coil domains 3
  unc-93 homolog B1, TLR signaling regulator
  zinc finger and BTB domain containing 48
  zinc finger protein 281

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.