GFUS, GDP-L-fucose synthase

GFUS, GDP-L-fucose synthase

• Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

• Gene Synonyms (GDP-L-fucose synthase, 3-5 epimerase/4-reductase, GDP-4-keto-6-deoxy-D-mannose epimerase-reductase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, red cell NADP(H)-binding protein, short chain dehydrogenase/reductase family 4E, member 1, testis tissue sperm-binding protein Li 45a, tissue specific transplantation antigen 3, tissue specific transplantation antigen P35B, FX, P35B, SDR4E1, TSTA3,)
• NCBI Gene ID: 7264
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13630
  UNIPROT ID#>>A0A140VKC8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GDP-L-fucose synthase interacts with:

• ADP ribosylation factor interacting protein 1
  BAG cochaperone 3
  Coenzyme A synthase
  dehydrogenase/reductase 11
  destrin, actin depolymerizing factor
  DnaJ heat shock protein family (Hsp40) member C9
  EF-hand domain family member D2
  exportin 1
  GDP-L-fucose synthase
  GIPC PDZ domain containing family member 1
  glutaredoxin 3
  guanine monophosphate synthase
  lysine demethylase 3A
  methionine adenosyltransferase 2B
  N-terminal Xaa-Pro-Lys N-methyltransferase 1
  poly(rC) binding protein 3
  programmed cell death 6
  protein phosphatase methylesterase 1
  RIO kinase 2
  SEC31 homolog A, COPII coat complex component
  ubiquitin C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.