UCHL3, ubiquitin C-terminal hydrolase L3

UCHL3, ubiquitin C-terminal hydrolase L3

• The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase isozyme L3, testicular tissue protein Li 221, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase), ubiquitin thioesterase L3, ubiquitin thiolesterase, UCH-L3,)
• NCBI Gene ID: 7347
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087WTB8
  UNIPROT ID#>>P15374
  UNIPROT ID#>>A0A140VJZ4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin C-terminal hydrolase L3 interacts with:

• 5'-nucleotidase domain containing 1
  acetyl-CoA acyltransferase 2
  adenosylhomocysteinase like 1
  alkylglycerone phosphate synthase
  apoptosis inducing factor mitochondria associated 1
  ataxin 7 like 3
  ATPase H+ transporting V1 subunit F
  BAG cochaperone 3
  caseinolytic mitochondrial matrix peptidase chaperone subunit B
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 7
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  DExD-box helicase 21
  DExD-box helicase 39A
  DExD-box helicase 39B
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 4A3
  ezrin
  FMR1 autosomal homolog 1
  H2B clustered histone 15
  inositol-3-phosphate synthase 1
  LIM domain and actin binding 1
  LON peptidase N-terminal domain and ring finger 1
  microtubule associated protein RP/EB family member 1
  neuronal vesicle trafficking associated 2
  NOP56 ribonucleoprotein
  nucleoporin 93
  OTU deubiquitinase with linear linkage specificity
  pogo transposable element derived with KRAB domain
  praja ring finger ubiquitin ligase 1
  RAB1B, member RAS oncogene family
  RAB7A, member RAS oncogene family
  sideroflexin 3
  solute carrier family 25 member 13
  SRP receptor subunit beta
  stress induced phosphoprotein 1
  tetratricopeptide repeat domain 9C
  transgelin 2
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  ubiquilin 1
  ubiquitin conjugating enzyme E2 S
  ubiquitin C-terminal hydrolase L3
  ubiquitin like 7
  ubiquitin like modifier activating enzyme 6
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 34
  ubiquitin specific peptidase 48
  ubiquitin specific peptidase 5
  ubiquitin specific peptidase 9 X-linked
  ubiquitination factor E4B
  UBX domain protein 7
  unk zinc finger
  VPS33B late endosome and lysosome associated
  X-ray repair cross complementing 5
  Yes1 associated transcriptional regulator
  zinc finger FYVE-type containing 19
  zinc finger MYM-type containing 6
  zinc finger protein 593
  zinc finger RANBP2-type containing 2
  zinc ribbon domain containing 2
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.