USP1, ubiquitin specific peptidase 1

USP1, ubiquitin specific peptidase 1

• This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 1, deubiquitinating enzyme 1, hUBP, ubiquitin specific processing protease 1, ubiquitin specific protease 1, ubiquitin thioesterase 1, ubiquitin thiolesterase 1, UBP,)
• NCBI Gene ID: 7398
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94782
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 1 interacts with:

• aldehyde dehydrogenase 16 family member A1
  anaphase promoting complex subunit 1
  arginine and serine rich protein 1
  ATPase family AAA domain containing 5
  BAG cochaperone 6
  calmodulin like 5
  ceramide kinase
  cullin 4A
  deltex E3 ubiquitin ligase 3
  dynactin 3
  FA complementation group I
  fizzy and cell division cycle 20 related 1
  karyopherin subunit alpha 7
  katanin catalytic subunit A1
  kelch domain containing 2
  leucine rich repeat containing 15
  nuclear factor of activated T cells 5
  PH domain and leucine rich repeat protein phosphatase 1
  PH domain and leucine rich repeat protein phosphatase 2
  PHD finger protein 7
  phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
  RAD51 associated protein 1
  receptor interacting serine/threonine kinase 1
  small glutamine rich tetratricopeptide repeat containing beta
  SNF2 histone linker PHD RING helicase
  suppressor of cytokine signaling 6
  synaptotagmin binding cytoplasmic RNA interacting protein
  TANK binding kinase 1
  torsin 1A interacting protein 1
  transgelin 2
  tripartite motif containing 46
  ubiquitin specific peptidase 1
  ubiquitin specific peptidase 43
  unc-45 myosin chaperone A
  unc-51 like autophagy activating kinase 1
  vacuolar protein sorting 36 homolog
  VPS26, retromer complex component A
  WD repeat domain 48
  WD repeat domain 48
  WD repeat domain 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.