VWF, von Willebrand factor

VWF, von Willebrand factor

• This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]

• Gene Synonyms (von Willebrand factor, coagulation factor VIII VWF, F8VWF, VWD,)
• NCBI Gene ID: 7450
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04275
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

von Willebrand factor interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 13
  protein disulfide isomerase family A member 4
  suppressor of cytokine signaling 4
  von Willebrand factor
  zinc finger protein 512B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.