POLR1B, RNA polymerase I subunit B

POLR1B, RNA polymerase I subunit B

• Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (DNA-directed RNA polymerase I subunit RPA2, DNA-directed RNA polymerase I 135 kDa polypeptide, DNA-directed RNA polymerase I 135kDa polypeptide, RNA polymerase I subunit 2, polymerase (RNA) I polypeptide B, 128kDa, polymerase (RNA) I subunit B, A135, RPA135, RPA2, Rpo1-2, TCS4,)
• NCBI Gene ID: 84172
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z1W6
  UNIPROT ID#>>Q9H9Y6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase I subunit B interacts with:

• egl-9 family hypoxia inducible factor 3
  ring finger and CCCH-type domains 1
  RNA polymerase I subunit B
  RNA polymerase I subunit F
  WD repeat domain 36

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.