PPFIBP1, PPFIA binding protein 1

PPFIBP1, PPFIA binding protein 1

• The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (liprin-beta-1, PTPRF interacting protein, binding protein 1 (liprin beta 1), PTPRF-interacting protein-binding protein 1, liprin related protein, protein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1, L2, SGT2, hSGT2, hSgt2p,)
• NCBI Gene ID: 8496
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RB02
  UNIPROT ID#>>Q86W92
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PPFIA binding protein 1 interacts with:

• centrosomal protein 250
  centrosomal protein 76
  DDB1 and CUL4 associated factor 7
  dynein light chain LC8-type 1
  elongation factor Tu GTP binding domain containing 2
  ETAA1 activator of ATR kinase
  filamin, beta
  hydroxyacid oxidase 2
  kinesin family member 21A
  KN motif and ankyrin repeat domains 2
  large tumor suppressor kinase 2
  myosin IC
  myosin, heavy polypeptide 9, non-muscle
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  PNKD metallo-beta-lactamase domain containing
  PPFIA binding protein 1
  PTPRF interacting protein alpha 1
  PTPRF interacting protein alpha 2
  PTPRF interacting protein alpha 3
  Rap guanine nucleotide exchange factor 5
  SH3 domain containing kinase binding protein 1
  suppressor of cancer cell invasion
  TNF superfamily member 13b
  transmembrane protein 17
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.