PIK3R3, phosphoinositide-3-kinase regulatory subunit 3

PIK3R3, phosphoinositide-3-kinase regulatory subunit 3

• Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]

• Gene Synonyms (phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, PI3K regulatory subunit gamma, phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma), phosphoinositide-3-kinase, regulatory subunit 3 (gamma), ptdIns-3-kinase regulatory subunit p55-gamma, p55, p55-GAMMA, p55PIK,)
• NCBI Gene ID: 8503
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N381
  UNIPROT ID#>>B4DXM8
  UNIPROT ID#>>Q7Z3W2
  UNIPROT ID#>>Q92569
  UNIPROT ID#>>Q68CY7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoinositide-3-kinase regulatory subunit 3 interacts with:

• adenine nucleotide translocase lysine methyltransferase
  ADP ribosylation factor like GTPase 6 interacting protein 4
  ankyrin repeat and sterile alpha motif domain containing 1A
  ATP binding cassette subfamily B member 6 (Langereis blood group)
  AT-rich interaction domain 4B
  aurora kinase A and ninein interacting protein
  basic leucine zipper nuclear factor 1
  BRICK1 subunit of SCAR/WAVE actin nucleating complex
  butyrophilin subfamily 2 member A1
  calcium/calmodulin dependent protein kinase I
  centrosomal protein 126
  centrosomal protein 19
  cereblon
  chordin like 2
  chromosome 9 open reading frame 24
  coiled-coil domain containing 14
  coiled-coil domain containing 196
  coiled-coil domain containing 33
  coiled-coil domain containing 89
  cytokine dependent hematopoietic cell linker
  DDB1 and CUL4 associated factor 8
  DISC1 scaffold protein
  DR1 associated protein 1
  DSN1 component of MIS12 kinetochore complex
  egl-9 family hypoxia inducible factor 3
  EH domain containing 2
  enkurin domain containing 1
  family with sequence similarity 166 member B
  fibrillin 3
  fibroblast growth factor receptor substrate 3
  fibronectin leucine rich transmembrane protein 1
  fibronectin type III and SPRY domain containing 2
  fibronectin type III domain containing 8
  hematopoietic SH2 domain containing
  HEPACAM family member 2
  hepatitis A virus cellular receptor 2
  homologous recombination factor with OB-fold
  insulin receptor substrate 2
  integrin subunit beta 3 binding protein
  IQ motif and ubiquitin domain containing
  KH RNA binding domain containing, signal transduction associated 1
  KIAA0408
  kinesin light chain 2
  Kruppel like factor 15
  L3MBTL histone methyl-lysine binding protein 3
  leucine aminopeptidase 3
  ligand of numb-protein X 2
  LUC7 like 2, pre-mRNA splicing factor
  lysine methyltransferase 2B
  MAP3K12 binding inhibitory protein 1
  metal response element binding transcription factor 2
  methyltransferase like 27
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  nebulette
  neuroligin 3
  nischarin
  oligodendrocyte transcription factor 1
  OTU deubiquitinase 7B
  par-6 family cell polarity regulator alpha
  parkin coregulated like
  PBX homeobox 4
  pellino E3 ubiquitin protein ligase family member 3
  pelota mRNA surveillance and ribosome rescue factor
  phospholipase B1
  pleckstrin homology and FYVE domain containing 2
  pleckstrin homology domain containing S1
  protein tyrosine phosphatase 4A3
  protocadherin beta 5
  receptor interacting serine/threonine kinase 4
  RELT TNF receptor
  retinol binding protein 7
  RUN and SH3 domain containing 1
  SERTA domain containing 2
  SH2 domain containing 2A
  single stranded DNA binding protein 4
  spermatogenesis associated 32
  splA/ryanodine receptor domain and SOCS box containing 2
  src kinase associated phosphoprotein 1
  suppressor of cytokine signaling 4
  suppressor of cytokine signaling 6
  tetraspanin 2
  transcription activation suppressor family member 2
  transmembrane protein 52B
  tripartite motif containing 54
  tRNA methyltransferase 2 homolog A
  tyrosine kinase non receptor 2
  ubiquitin specific peptidase 2
  V-set and immunoglobulin domain containing 4
  WD repeat and FYVE domain containing 3
  WRN helicase interacting protein 1
  yippee like 3
  zinc finger and BTB domain containing 18
  zinc finger matrin-type 1
  zinc finger protein 281
  zinc finger protein 451
  zinc finger protein 620

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.