SKAP1, src kinase associated phosphoprotein 1

SKAP1, src kinase associated phosphoprotein 1

• This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

• Gene Synonyms (src kinase-associated phosphoprotein 1, SKAP-55, epididymis secretory sperm binding protein Li 81p, pp55, src family-associated phosphoprotein 1, src kinase-associated phosphoprotein of 55 kDa, HEL-S-81p, SCAP1, SKAP55,)
• NCBI Gene ID: 8631
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q86WV1
  UNIPROT ID#>>V9HW03
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

src kinase associated phosphoprotein 1 interacts with:

• adaptor related protein complex 3 subunit mu 1
  amyloid beta precursor protein binding protein 2
  assembly factor for spindle microtubules
  BLCAP apoptosis inducing factor
  centriolar coiled-coil protein 110
  dedicator of cytokinesis 7
  dynein light chain LC8-type 2
  elongator acetyltransferase complex subunit 3
  EMAP like 3
  exophilin 5
  family with sequence similarity 102 member A
  HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
  junctophilin 1
  kelch domain containing 3
  kinase suppressor of ras 1
  MAP7 domain containing 1
  minichromosome maintenance 8 homologous recombination repair factor
  MYC binding protein 2
  myotubularin related protein 1
  nephrocystin 4
  non-SMC condensin II complex subunit D3
  non-SMC condensin II complex subunit H2
  p53 and DNA damage regulated 1
  periphilin 1
  pleckstrin homology like domain family B member 3
  pleckstrin homology, MyTH4 and FERM domain containing H3
  PML-RARA regulated adaptor molecule 1
  proline rich 14 like
  protein kinase N3
  pseudouridine synthase like 1
  RecQ like helicase 4
  regulator of telomere elongation helicase 1
  RNA exonuclease 5
  RNA polymerase I and III subunit D
  RNA polymerase I subunit A
  RNA polymerase I subunit B
  RNA polymerase I subunit E
  RNA polymerase I subunit G
  RNA polymerase III subunit A
  RNA polymerase III subunit B
  SEC63 homolog, protein translocation regulator
  senataxin
  SET domain containing 5
  SH2 domain containing 4A
  src kinase associated phosphoprotein 1
  src kinase associated phosphoprotein 2
  succinyl-CoA:glutarate-CoA transferase
  SUMO specific peptidase 5
  tigger transposable element derived 5
  transcription activation suppressor
  transducin beta like 2
  tRNA methyltransferase 1
  tRNA methyltransferase 44 homolog
  ubiquitin specific peptidase 54
  URI1 prefoldin like chaperone
  uridine-cytidine kinase 1 like 1
  UTP15 small subunit processome component
  zinc finger HIT-type containing 6
  zinc finger protein 324
  zinc finger protein 644

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.