TNFSF10, TNF superfamily member 10

TNFSF10, TNF superfamily member 10

• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

• Gene Synonyms (tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis inducing ligand TRAIL, chemokine tumor necrosis factor ligand superfamily member 10, tumor necrosis factor (ligand) family, member 10, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor apoptosis-inducing ligand splice variant delta, tumor necrosis factor ligand 6A, tumor necrosis factor superfamily member 10, APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL,)
• NCBI Gene ID: 8743
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6IBA9
  UNIPROT ID#>>P50591
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF superfamily member 10 interacts with:

• CASP8 and FADD like apoptosis regulator
  Fas associated via death domain
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  immediate early response 3
  RNA binding motif protein 48
  suppressor of cytokine signaling 3
  TNF receptor superfamily member 10a
  TNF receptor superfamily member 10b
  TNF receptor superfamily member 10c
  TNF receptor superfamily member 10d
  TNF superfamily member 10
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.